FOOD AND BEVERAGE MEMBRANE FILTRATION

Actinomycetes fermentation broth clarification and filtration(2025年)

Bonatech — 2025-03-05T18:23:38+0900

https://bona-filtration.com/vancomycin-purification/

Vancomycin purification, isolation, extraction(information):
Vancomycin is a glycopeptide antibiotic isolated from Streptomyces orientalis. It is currently the first choice for the treatment of penicillin-resistant bacteria and those allergic to β-lactam antibiotics. It has been hailed by international antibiotic experts as “the last line of defence for humans against persistent drug-resistant strains”. As public awareness of drug safety increases, the pharmaceutical industry is demanding ever-higher standards of purity for vancomycin. The United States Pharmacopoeia requires a purity of 90% for vancomycin.

The system for producing daptomycin by microbial fermentation is very complex. The fermentation broth contains a large amount of impurities such as unused culture medium, microbial cells and their metabolites, and the presence of these impurities has caused significant difficulties in the separation and purification of daptomycin. Bona Technology uses ceramic membranes, developed and manufactured in-house, to achieve high-precision, high-throughput filtration and clarification of daptomycin fermentation broth, together with control of filtration process parameters to significantly reduce energy consumption and production costs. After the clarified fermentation broth is subjected to a series of processes such as chromatography, it is concentrated by optimising Bona Technology’s superior performance nanofiltration membrane, and then freeze-dried after concentration to a certain degree to obtain a high-purity daptomycin raw material. Instead of traditional organic solvent extraction, chromatography and other processes, it avoids the use of large amounts of solvents, complicated procedures and large equipment investment, and realises a new, efficient and low-cost separation and purification of daptomycin.

Plant extract clarification(2025年)

Bonatech — 2025-03-05T18:15:39+0900

https://bona-filtration.com/blueberry-extract/

Blueberry Extract (information):
Blueberries are a rich source of nutrients, including carbohydrates, proteins, lipids, vitamins, dietary fibre and minerals. They also contain significant levels of anthocyanins, which are known for their health benefits. Blueberries offer a wide range of functional factors that contribute to various health benefits, such as promoting eye health, enhancing immune function, reducing inflammation, preventing brain and cardiovascular diseases, and fighting oxidation and cancer.

Traditional extraction blueberry extract:
The conventional method of extracting active ingredients from blueberries primarily involves the use of solvent extraction or water extraction and alcohol precipitation. However, this approach is associated with challenges, including low extraction efficiency, the presence of numerous impurities, and high solvent consumption.

Membrane filtration technology applied to blueberry extract:
Bonatech ceramic membranes, developed and manufactured independently, significantly enhance the concentration of purified materials and the content of active ingredients. Customers can select ultrafiltration membranes with different molecular weight cutoffs, tailored to the particle size and molecular weight of the substances to be separated. During the process, the materials do not undergo a phase change, and the operating conditions are mild, minimising the loss of active ingredients. This process is energy efficient and straightforward to operate.

If you have any questions or want to know more about the process and equipment, please contact us

Plant extract clarification(2025年)

Bonatech — 2025-03-05T18:01:11+0900

https://bona-filtration.com/licorice-extract/

Licorice Extract (information):
Licorice extract is a medicinal ingredient extracted from licorice. Licorice extract generally contains glycyrrhizin, glycyrrhizic acid, glycyrrhizin, licorice flavonoids, hyoscyamine, formononetin, pelargonine and other ingredients. It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving pain and harmonizing various medicines.
Traditional methods for refining licorice extracts mostly use alcohol precipitation, adding appropriate ethanol to the licorice water extract to precipitate and remove impurities such as mucus, gelatinized starch, pectin, and protein.
However, the process is complicated, the solvent consumption is large, the effective ingredients are easily lost, and the separation efficiency is low.

Membrane filtration technology applied to licorice extract:
Bonatech uses an integrated membrane separation process that combines ceramic membrane separation technology with organic membrane ultrafiltration and nanofiltration separation technology to form a step-by-step filtration separation. The ultrafiltration membrane system is used for clarification and impurity removal, and the nanofiltration membrane system is used for small molecule impurity removal and concentration, which can achieve efficient purification of licorice extracts, and there is no phase change in the process, low energy consumption and no pollution.

If you have any questions or want to know more about the process and equipment, please contact us