Beijing Beilu Pharmaceutical Co., Ltd

Gadobenate Dimeglumine Injection(2024年03月17日)

beilupharma — 2024-03-12T16:36:55+0900

https://www.beilupharma.com/products/gadobenate-dimeglumine-injection.html

Gadobenate Dimeglumine Injection

For more information about types of gadolinium contrast and gadobenate dimeglumine, please feel free to contact us!

Founded in 1992, Beilu is mainly engaged in the research & development, production and sales of pharmaceutical products. It is high-tech innovation company with core competence in the Contrast Media domestic.

To Understand the Development of Iodinated Contrast Agents(2024年03月16日)

beilupharma — 2024-03-12T16:36:29+0900

https://www.beilupharma.com/to-understand-the-development-of-iodinated-contrast-agents.html

For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of the body's local tissues. This substance is called "Contrast Media". Iodinated contrast agent is the most commonly used X-ray contrast agent, and it is also the basic diagnostic drug for cardiovascular imaging under X-ray.

1. The development history of iodinated contrast agents
Since its development, the iodine based contrast dye has undergone a development process from ionic to non-ionic, from hypertonic to hypotonic and to isotonic:

(1) Hypertonic contrast agent is an ionic monomer, and its osmotic pressure is as high as 5-7 times of plasma osmotic pressure; due to relatively more adverse reactions, it has been rarely used at present.

(2) The iodinated diagnostic agents is named according to that its osmotic pressure is significantly lower than that of the ionic hypertonic contrast agent (such as diatrizoate meglumine), which includes two types of contrast agents: non-ionic monomer and ionic dimer. Its osmotic pressure is about twice that of plasma.

(3) The iodine based contrast agents was developed to further reduce the osmotic pressure after the hypotonic contrast agent. The isotonic contrast agent is a non-ionic dimer whose osmotic pressure is equal to the plasma osmotic pressure.

2.Types of iodine based contrast media
According to the iohexol iodine package insert, the basic structure of the current clinically used iodine-containing iohexol contrast is 3-acetyl-2,4,6-tribenzoic acid, which is a benzene ring containing 3 iodine. According to different properties, contrast agents can be divided into monomer and dimer contrast agents, ionic and nonionic iodinated contrast, hypertonic, sub-hypertonic and isotonic contrast agents (Table 1).

If you need any kinds of contrast medium, please contact us, as a professional contrast media manufacturing companies, Bei lu is willing to offer you high quality products.

Repaglinide Tablets(2024年03月15日)

beilupharma — 2024-03-12T16:36:04+0900

https://www.beilupharma.com/products/repaglinide-tablets.html

Repaglinide tablets are non-sulfonylurea insulin secretion agents and are used to treat patients with type 2 diabetes. Repaglinide 0.5 mg oral tablet were listed in China in 2000, and it is a Class B drug in the National Medical Insurance List. Repaglinide 0.5 tablet have been listed as a drug for diabetic patients with renal insufficiency by many guidelines at home and abroad.

Product name: Repaglinide Tablets
Characteristic: White or off-white tablet
Specification: repaglinide 0.5mg×30 tablets, repaglinide 0.5mg×60 tablets.

Indications：
It is used for type 2 diabetes (non-insulin-dependent) patients whose hyperglycemia cannot be effectively controlled by diet control, weight loss and exercise. When metformin alone cannot effectively control hyperglycemia, repaglinide 2 mg tablet can be combined with metformin. Treatment should start from the adjuvant treatment of diet control and exercise to reduce blood sugar during meals.

Specifications of repaglinide 0.5 mg tablet: 0.5mg

Usage and Dosage，Adverse reactions，Contraindications，Precautions：

Please refer to the package insert.

Medicine Interactions:
Some drugs are known to affect glucose metabolism. Therefore, doctors should consider possible drug interactions.

In vitro studies have shown that the metabolism of Repaglinide is affected by CYP2C8 and CYP3A4. Repaglinide was found to be a substrate for active liver uptake (organic anion transporter OATP1B1).

Data from clinical studies carried out in healthy volunteers show that CYP2C8 is the main enzyme in the metabolism of Repaglinide, while CYP3A4 has limited effects. But if the effect of CYP2C8 is inhibited, the effect of CYP3A4 will be relatively enhanced. Therefore, the metabolism and clearance of Repaglinide may be changed due to the inhibition or induction of cytochrome P450. Therefore, extreme caution should be exercised when using CYP2C8 and CYP3A4 inhibitors simultaneously with Repaglinide. Drugs that inhibit OATP1B1 (such as cyclosporine) may increase the plasma concentration of Repaglinide. ( For more details, please refer to the package insert.

Storage: Similar to the storage of repaglinide tab 0.5 mg, tab repaglinide should also be shaded, sealed, kept in a dry place.

Packaging:
Aluminum plastic packaging, 15 pills/plate , 2 plates/box; 15 pills/plate, 4 plates/box, 15 pills/plate, 6 plates/box

Shelf life: 24 months

For more information about repaglinide tablets brand name and types of mri contrast, please feel free to contact us!

Founded in 1992, Beijing pharmaceuticals is mainly engaged in the research & development, production and sales of pharmaceutical products. It is high-tech innovation contrast ltd.

MRI Contrast Media(2024年03月14日)

beilupharma — 2024-03-12T16:35:37+0900

https://www.beilupharma.com/products/mri-contrast-media/

Magnetic resonance imaging Contrast Media (MRI Contrast Media), also called Magnetic resonance imaging Contrast Agents, which is Gadolinium based contrast agent (GBCA), mainly refers to: after being introduced into the body through a certain way (generally intravenous injection), the MRI contrast media can produce more obvious image contrast between interest range and surrounding tissues. Different from the iodinated Contrast Media of CT/X-ray, the MRI Contrast Media acts indirectly by affecting the proton relaxation time of the molecule. When entering the blood vessels and tissues of the gadolinium-containing Contrast Media in the body, the MRI contrast media products can shorten the relaxation time of T1 to enhance image contrast. The classic contrast media used in mri has wide indications, high detection rate, high safety and cost-effectiveness.

Safety of Gadolinium Contrast Media
Acute reactions

Gadolinium contrast material for mri possess a very low incidence ( < 2.5 % ) of acute adverse reactions compared to many other drugs. Almost all of their reactions are very mild, the most common are nausea, headache, discomfort at the injection site, vomiting, metallic taste, paresthesia, fever and dizziness.

Immediate hypersensitivity reactions may occur within 1 hour of imaging agents administration, it is approximately 1 in 1000 cases. These are more likely to occur in patients with allergies, asthma, and allergic reactions to gadolinium contrast agents. The most common of these reactions are mild pruritus ( itching ) and urticarial ( hives ). The moderate hypersensitivity reactions occur in about 1 in 5000 cases, it usually includes bronchospasm, facial oedema, arrhythmias, laryngospasm, tachycardia, or widespread urticarial(hives).

The incidence of severe reactions is about 1 in 20,000. A number of severe anaphylactoid reactions to Gd MRI Contrast Media, including death, have been reported worldwide, the risk of death is about 1 in 400,000.

Chronic Reactions MRI Contrast Media-Chronic reactions

NSF ( Nephrogenic Systemic Fibrosis ) is the most famous of Chronic reactions to Ga Contrast Media. It is a disease of fibrosis of the skin and internal organs, which occurs in patients with chronic severe renal insufficiency. Several hundred patients have been diagnosed worldwide since the first reported case in 2006. NSF has now been largely eliminated as an existing disease with the efforts of the biology community. However, Gd-containing plaques in the extremities have been reported and may represent a forme fruste of NSF.

The US FDA believes that although medical literature reports that there is the deposition of gadolinium-containing Contrast Media in the brain tissue of some patients undergoing 4 or more MRI scans, so far, there are no harmful symptoms, signs, and pathological changes appearing associated with the gadolinium-based contrast agent deposition in brain tissue. In its database of adverse event reporting system, the FDA has received many adverse event reports of patients experiencing pain or other symptoms after single or multiple applications of gadolinium-containing Contrast Media. However, so far, the FDA hasn't been able to clarify common features in these reports. It is not proven yet that the reported symptoms are reasonably related to gadolinium. Further information is needed to evaluate the possible risks caused by gadolinium deposition.

In conclusion, although the incidence of adverse reactions of the gadolinium Contrast Media used in the MRI enhancement examination is very low, one should always keep in mind that any drug administration carries with it the risk of life-threatening reaction, and long-term risks of gadolinium contrast medium deposition must be considered.

For more information about mri intravenous contrast and different types of mri contrast, please feel free to contact us!

Founded in 1992, Beijing pharmaceuticals is mainly engaged in the research & development, production and sales of pharmaceutical products. It is high-tech innovation contrast ltd.

Ioversol(2024年03月13日)

beilupharma — 2024-03-12T16:35:07+0900

https://www.beilupharma.com/products/ioversol.html

Ioversol
CAS No.: 87771-40-2
Molecular formula: C18H24I3N3O9
Molecular Weight: 807.11
Quality standard: CP, USP
Characteristics: White or almost white powder
Content (HPLC): ≥99.0%
Packing: 25KG, 50KG/drum
Storage: Protected from light, sealed tightly

For more information about ioversol, please feel free to contact us!

If you need any kinds of contrast medium, please contact us, as a professional contrast media companies, Beijing beilu pharmaceutical co ltd is willing to offer you high quality products.

Iopamidol Intermediate (order based) 5-Amino-2,4,6-triiodoisophthalic acid(2024年03月12日)

beilupharma — 2024-03-12T16:34:42+0900

https://www.beilupharma.com/products/iopamidol-intermediate.html

CAS No.: 35453 19 1
Molecular formula: C8H4I3NO4
Molecular weight: 558.84
Quality standard: CP, USP
Content (HPLC): ≥99.0%
Packing: 25KG, 50KG/drum
Storage: Protected from light, sealed tightly

If you need any kinds of contrast medium, please contact us, as a professional contrast media manufacturer, Beijing beilu pharmaceutical co ltd is willing to offer you high quality products.

Iopamidol Injection(2024年02月26日)

beilupharma — 2024-02-26T16:05:19+0900

https://www.beilupharma.com/products/iopamidol-injection.html

Iopamidol Injection is the second-generation non-ionic iodinated Contrast Media launched in the global market. In 2015, Beilu firstly launched and listed Iopamidol Injection, one of the most widely used types of contrast medium in the Chinese market.

Product name: iopamiro injection

Generic name: Iopamidol Injection

Type: Injectable Contrast Media for CT/X-ray

Ingredients: Iopamidol

Specification:

(1) 50ml: 15 gl

(2) 100ml: 30 gl

(3) 50ml: 18.5 gl

(4) 100ml: 37 gl

Administration: Intravascular injection

Adverse reactions: The application of organic iodine compounds can cause adverse reactions, as well as allergic or drug-induced shock. See the details from the package insert

Shelf life: 36 months

Advantages of Iopamidol 300 Injection
High enhancement value, which increased the contrast between the lesion and solid organs, improved the lesion detection.

Low viscosity

Low osmotic pressure

Low injection speed, which reduces vascular pressure and prevents contrast media extravasation (patient with poor tolerance, such as children, elderly, diabetes or tumor patients, are more suitable for high-concentration contrast media)

The low total dosage of Contrast media

Low radiation dose

Indications of iopamidol 370 Injection
Neuroradiology: Spinal nerve root angiography, Cisternography and ventriculography.

Angiography: Cerebral arteriography, Coronary angiography, Thoracic aorta and abdominal aorta angiography, Angiocardiography, Selectivevisceral arteriography, Peripheral arteriography and venography, Digital subtraction angiography of cerebral arteries, peripheral arteries and abdominal arteries.

Urinary system angiography: Venous urography, Enhanced scan in CT examination, Arthrography, Fistula angiography, Digital subtraction angiography.

Precautions please refer to the package insert.

Iohexol Injection(2024年02月26日)

beilupharma — 2024-02-26T16:04:49+0900

https://www.beilupharma.com/products/iohexol-injection.html

Iohexol oral is one of the different types of contrast media. Compared with a traditional ionic Contrast Media, Iohexol Injection has an excellent molecular structure and it can greatly improve user safety and significantly reduce adverse reactions. The iodinated contrast agent has excellent clinical feedback and good imaging results. In 1998, Iohexol Injection was launched as Beilu's 1st iodinated Contrast Media.

iohexol brand name: Iohexol Injection

Generic name: Iohexol Injection

Type: Injectable Contrast Media for CT/X-ray

Ingredients: Iohexol

Specification:

(1) 20 ml: 6 gI (2) 50 ml: 15 gI

(3) 75 ml: 22.5 gI (4) 100 ml: 30 gI

(5) 20 ml: 7 gI (6) 50 ml: 17.5 gI

(7) 100 ml: 35 gI

Administration: For injection or oral use of iodinated contrast

Adverse reactions: See the details from the package insert

Shelf life: 36 months

Indications of Iohexol Injection
The omnipaque iohexol is an X-ray contrast agent. It can be used for angiocardiography, arteriography, urography, enhanced CT examination inclduing cervical, thoracic and lumbar myelography, CT cisternography following intrathecal injection (i.e., an injection into the subarachnoid space); arthrography, endoscopic retrograde cholangiopancreatography (ERCP), herniography or fistulography, hysterosalpingography, sialography, percutaneous transhepatic cholangiography (PTC), sinography, gastroenterography, T-tube angiography, etc.

Precautions of Iohexol Injection
General precautions for the use of nonionic-monomer contrast agent:

1. Special attention should be paid to patients with allergies, asthma and adverse reactions to iodinated contrast agents. Prophylactic medications such as steroids and H1/H2 histamine receptor antagonists may be considered for these patients.

2. The risk of serious reactions related to this type of CT contrast agent is low. However, iodinated contrast agents can provoke anaphylactoid reactions or other allergic reactions. Therefore, first aid measures should be trained in advance, and necessary rescue drugs and devices should be prepared for possible serious reactions.

3. In view of the low accuracy of pre-test in predicting allergic reactions caused by nonionic contrast agents and the possibility that the pre-test itself may lead to serious allergic reactions, it is not recommended to use pretest to predict iodine allergic reactions.

4. Venous access should be kept smooth throughout the X-ray examination.

5. In the in-vitro tests, the iohexol side effects of nonionic contrast agents on the coagulation system is lighter than that of ionic contrast agents. During angiography, great care should be taken in the intravascular technical procedures, and the catheter should be irrigated with heparinized saline from time to time to reduce the thrombosis and embolism related to the technical procedures.

6. Patients, especially patients with multiple myeloma, diabetes, renal insufficiency, infants and young children, and the elderly, must be appropriately hydrated before and after the use of contrast agent. Electrolyte disturbance and hemodynamic disorders are common in infants (< 1 year old), particularly neonates. Special attention should be paid to patients with serious heart diseases and pulmonary arterial hypertension because they are prone to developing hemodynamic disorders and cardiac rhythm disturbances.

7. Patients with acute encephalopathy, brain tumour or history of epilepsy should be prevented from seizures, and special attention should be paid to them. The risks of seizures and neurologic reactions are significantly increased in patients with alcohol or drug abuse. Transient hearing loss or deafness occurs in a few patients after myelography, which is possibly caused by a decrease in CSF pressure after lumbar puncture.

8. In view of the high risks of acute renal failure after the use of contrast agent, special attention should be paid to patients with pre-existing renal impairment and diabetes and patients with atypical globulinemia (multiple myelomatoses and Waldenstrom macroglobulinemia).

9. Preventive actions include:

Identify patients with high-risk factors.

Ensure patients are appropriately hydrated and, if necessary, the infusion may be maintained intravenously prior to examination until the contrast agent is cleared from the kidneys.

Avoid any nephrotoxic agent, oral gallbladder contrast agent, surgery for arterial occlusion, renal angioplasty or other major surgeries that increase the renal burden until the contrast agent is cleared.

Repeat radiographic testing is delayed until renal function returned to the pre-examination level.

To prevent lactic acidosis, the level of serum creatinine must be determined before intravascular injection of iodinated contrast agent into diabetic patients taking metformin. For patients with abnormal serum creatinine/renal function, metformin must be discontinued and the examinations with contrast agent must be postponed until after 48 hours of discontinuation. Metformin should be reused only after renal function and serum creatinine level are constant. In some emergency cases of patients with abnormal or unknown renal function, the physician must assess both advantages and disadvantages of using contrast agent and take precautions, such as discontinuation of metformin, adequate hydration of patients, testing of renal functions, and careful observation of symptoms of lactic acidosis.

There is a potential risk of transient hepatic dysfunction. Special attention should be paid to patients with serious hepatic and renal insufficiency due to significantly longer time to clear contrast agent. Hemodialysis patients may receive the examinations with contrast agents. Immediate hemodialysis is not necessary after the injection of contrast agent because there is no evidence showing that hemodialysis can protect patients with renal impairment from contrast-induced nephropathy.

Iodinated contrast agents may exacerbate symptoms of myasthenia gravis. Patients with pheochromocytoma should be treated with α-blockers to prevent hypertensive crisis in interventional procedures. Special attention should also be paid to patients with hyperthyroidism. Patients with multinodular goitre may develop hyperthyroidism after using iodinated contrast agents. The possibility of transient hypothyroidism in preterm infants after using contrast agents should be clearly recognized.

Contrast media extravasation (CME) occasionally causes localized pain or oedema, which gradually subsides without sequelae. However, inflammation and even tissue necrosis may occasionally occur. Routine treatment is to elevate the affected limb and cold-compress at local sites. Surgical decompression is required in case of compartment syndrome.

10. Observation time:

Patients should be observed for at least 30 minutes after the use of the contrast agent because most serious adverse reactions occur during this period. However, there is still the possibility of a delayed response.

11. Intraspinal injection:

After myelography, patients should rest for 1 h with 20°-raised head and chest. Patients can carefully get out of bed and walk without bending over. If patients are still in bed, keep their head and chest raised for 6 hours. Patients with low seizure thresholds should be closely monitored during this period, and outpatients should not stay alone for the first 24 hours.

12. Effects on the ability to drive vehicles and operate machines:

Do not drive a vehicle or operate a machine within 24 hours after intraspinal injection.

13. As with all non-gastrointestinal drugs, this product should be visually inspected before use to check for particulate matter, discoloration and container damage.

Beijing beilu pharmaceutical co ltd is a professional contrast media manufacturing companies, we provide ct contrast agent, omnipaque package insert, iohexol 300, contrast media products and etc. Want to know what is iohexol and iohexol uses? Please contact us.

Iodixanol Injection(2024年02月26日)

beilupharma — 2024-02-26T16:04:16+0900

https://www.beilupharma.com/products/iodixanol-injection.html

Iodixanol Injection is a CT/X-ray Contrast Media that is isotonic with plasma. It has excellent cardiac safety and renal safety, which is most comfortable to use, especially suitable for high risk patients. Gadopentetate Dimeglumine Injection is also available here.

Product name: Iodixanol Injection

Generic name: Iodixanol Injection

Type: Injectable Contrast media for CT/X-ray

Ingredients: Iodixanol

Specification:

(1)100ml-27 gl

(2)50ml-16 gl

(3)100ml-32 gl

Administration: For Intravascular use only

Adverse reactions: See the details from the package insert

Shelf life: 24 months

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As one of the most professional contrast media companies, Beilu provides ct contrast agent, mri contrast medium, visipaque package insert, visipaque contrast media, iodixanol visipaque, visipaque contrast, visipaque 320, visipaque and etc. Want to know more? Please contact us.

Glimepiride Tablets(2024年02月26日)

beilupharma — 2024-02-26T16:03:42+0900

https://www.beilupharma.com/products/glimepiride-tablets.html

Glimepiride 1 Tablet is a sulfonylurea hypoglycemic drug that can be used in combination with insulin. In 2001, glimepiride 2 tablet (Dibei), as the first hypoglycemic product of Beilu Pharma, was first listed in China and belongs to the second class of national new drugs.

Product name: Glimepiride Tablets
Specifications: glimepiride 1 mg×30 tablets；glimepiride 2 mg×15 tablets；glimepiride 2mg×30 tablets

Characteristics: White tablet

Indications :

As one of the oral antidiabetic drugs produced by Beilu Pharma, our glimepiride tablets are only suitable for type 2 diabetes that cannot fully control blood sugar through diet control, exercise therapy and weight loss.

Glimepiride tablets are not suitable for type 1 diabetes (for example, the treatment of diabetic patients with a history of ketoacidosis), diabetic ketoacidosis or Treatment of pre-diabetic coma or coma.

Usage and Dosage: Please refer to the package insert

Adverse reactions, Contraindications, Precautions: Please refer to the package insert.

Storage: Shade, seal, and keep in a dry place.

Packaging: Aluminum plastic packaging, 15 pillsate, 1 plate/box; 15 pillsate, 2 plates/box.

Shelf life: 24 months

Advantages of Glimepiride Tablets
Double effect directly hit the hypoglycemic core

Double effect: Glimepiride tablets can promote insulin secretion and improve insulin resistance. At the same time, it can improve the two major pathophysiological abnormalities of insulin secretion and insulin resistance in patients with type 2 diabetes.

Efficiently reduce postprandial blood glucose, fasting blood glucose and glycosylated haemoglobin
Glimepiride 2 mg oral tablet monotherapy can comprehensively reduce FPG PPG and HbA1c in newly diagnosed T2DM patients

Combination therapy, such as combined metformin, acarbose, etc., has a more significant overall hypoglycemic effect

Less hypoglycemia, less weight impact, high safety

Short-term treatment, the risk of glimepiride hypoglycemia is only 1/3 of that of Glibenclamide

Long-term treatment, the risk of glimepiride hypoglycemia is only 1/7of that of Glibenclamide

Glimepiride has a small impact on the weight of T2DM patients

Once a day to improve patient compliance

If the patient's compliance is poor, Glimepiride tablets should be selected, once a day.

Beijing pharmaceuticals is a professional contrast media manufacturer, we provide glimepiride 1mg tablets, glimepiride tab 1mg, glimepiride package insert, mri contrast medium and etc. Want to know glimepiride 2mg tablets used for or side effects of glimepiride 1mg tablet? Please contact us.

Gadopentetate Dimeglumine Injection/API(2024年02月26日)

beilupharma — 2024-02-26T16:03:09+0900

https://www.beilupharma.com/products/gadopentetate-dimeglumine-injection-api/

Since Gadopentetate Dimeglumine Injection was launched in 1992 by Beilu Pharma in China, it was highly recommended and accepted by the radiologist, and quickly occupied the market with its excellent quality and reasonable price. Up to now, linear gadolinium has been safely used for nearly 30 years, with excellent enhancement effects and few side effects. Bei lu also produces gadobutrol injection with high quality and reasonable price, contact us for more info!

Product name: Gadopentetate Dimeglumine Injection

Generic name: Gadopentetate Dimeglumine Injection

Type: Injectable Contrast Media for MRI, Linear Contrast Media

No.1 market share in China

Ingredients: Gadopentetate Dimeglumine

Specification: 10ml:4.69 g; 12ml:5.63 g; 15ml:7.04 g; 20ml:9.38 g

Posology and method of administration: Intravenous injection

Adverse reactions: See the details from the package insert

Shelf life: 36 months

Indication of Gadopentetate Dimeglumine Injection
Magnetic resonance imaging of the central nervous system (brain and spinal cord), abdomen, chest, pelvis, limbs and other human organs and tissues.

Precautions of Gadopentetate Dimeglumine Injection
1. Use with caution in patients with severe kidney damage, epilepsy, hypotension, asthma and other allergic respiratory diseases and those with allergic tendencies.

2. Take care to avoid the extravasation of the gadopentetic acid liquid during injection to prevent tissue pain.

3. The serum iron and bilirubin levels of some patients will increase slightly after medication, but they are asymptomatic and can return to normal within 24 hours.

4. Pregnant women and breastfeeding women should use it with caution. Animal experiments show that a small amount of medicine liquid enters the milk.

5. The effective enhancement time of Magnevist contrast is 45 minutes. MRI examination should be performed immediately after intravenous injection.

6. The remaining medicine liquid after one examination should not be used again.

7. When applying this type of MRI contrast media, follow the relevant safety regulations in magnetic resonance imaging.

8. GBCAs should be used with caution. When plain scan MRI cannot obtain the corresponding vital diagnostic information, GBCAs can be used, and the lowest approved dose is used as much as possible.

9. Gadolinium deposition

Current evidence shows that after repeated use of GBCAs, trace amounts of gadolinium can remain in the brain and other body tissues. Research reports have shown that multiple uses of GBCAs can increase the intensity of brain signals, especially in the dentate nucleus and globus pallidus. Currently, there are more reports about linear GBCAs and fewer reports about macrocyclic GBCAs. Animal experiments have shown that the amount of gadolinium deposited after repeated use of linear GBCAs is higher than that of repeated use of macrocyclic.

The clinical significance of brain gadolinium deposition is unclear.

In order to minimize the potential risks associated with gadolinium deposition in the brain, it must be used in strict accordance with the indications and approved doses. It is recommended to use the lowest approved dose that meets the requirement of diagnosis and perform a careful benefit-risk assessment and patient informed communication before repeated administration.

Gadobutrol Injection/API(2024年02月26日)

beilupharma — 2024-02-26T16:02:30+0900

https://www.beilupharma.com/products/gadobutrol-Injection-api.html

In 2020, Beilu launched its macrocyclic Contrast Media- Gadobutrol Injection, it is gadolinium-based non-ionic Contrast Media, a paramagnetic Contrast Media used in various parts of the body lesion (including the brain and spinal cord) MRI imaging and angiography examination. Its macrocyclic nature ensures it is well-tolerated with a good safety profile for MRI Contrast. As a professional contrast media manufacturer, Beilu can provide you with the high concentration gadobutrol gadovist that leads to a better image with lower volume. We also provide DTPA acid with high quality.

Product name: Gadobutrol Injection

Generic name: Gadobutrol Injection

Type: Injectable Contrast Media for MRI, Macrocyclic Contrast Media

Ingredients: Gadobutrol

Specification:gadovist 7.5 ml: 4.5354 g

Administration: Intravenous administration only.

Adverse reactions: See the details from the package insert.

Shelf life: 24 months

Indication of Gadopentetate Dimegumine Injection
Magnetic resonance imaging of the central nervous system (brain and spinal cord), abdomen, chest, pelvis, limbs and other human organs and tissues.

Precautions of Gadopentetate Dimegumine Injection
1. Use with caution in patients with severe kidney damage, epilepsy, hypotension, asthma and other allergic respiratory diseases and those with allergic tendencies.

2. Pay attention to avoid the extravasation of the liquid during the gadobutrol injection uses so as to prevent tissue pain.

3. The serum iron and bilirubin levels of some patients will increase slightly after medication, but they are asymptomatic and can return to normal within 24 hours.

4. Pregnant women and breastfeeding women should use it with caution. Animal experiments show that a small amount of medicine liquid enters the milk.

5. The effective enhancement time of this product is 45 minutes. MRI examination should be performed immediately after intravenous injection.

6. The remaining medicine liquid after one examination should not be used again.

7. When applying the gadovist dose, follow the relevant safety regulations in magnetic resonance imaging.

8. GBCAs should be used with caution. When plain scan MRI cannot obtain the corresponding vital diagnostic information, GBCAs can be used, and the lowest approved dose is used as much as possible.

9. Gadolinium deposition

The clinical significance of brain gadolinium deposition is unclear.

Gadobenate Dimeglumine Injection(2023年10月06日)

beilupharma — 2023-09-21T11:15:34+0900

https://www.beilupharma.com/products/gadobenate-dimeglumine-injection.html

As one of the most professional contrast media companies, beijing beilu pharmaceutical co ltd provides glimepiride and contrast dye, gadobenate, gadobenate dimeglumine and etc.want to know more, contact us.

To Understand the Development of Iodinated Contrast Agents(2023年10月05日)

beilupharma — 2023-09-21T11:14:59+0900

https://www.beilupharma.com/to-understand-the-development-of-iodinated-contrast-agents.html

1. The development history of iodinated contrast agents
Since its development, the iodinated radiocontrast dye has undergone a development process from ionic to non-ionic, from hypertonic to hypotonic and to isotonic:

(2) The hypotonic contrast agent is named according to that its osmotic pressure is significantly lower than that of the ionic hypertonic contrast agent (such as diatrizoate meglumine), which includes two types of contrast agents: non-ionic monomer and ionic dimer. Its osmotic pressure is about twice that of plasma.

(3) The iodine based contrast agents was developed to further reduce the osmotic pressure after the iodine based contrast agent. The iodinated diagnostic agents is a non-ionic dimer whose osmotic pressure is equal to the plasma osmotic pressure.

2.Types of iodinated Contrast Media
According to the iohexol package insert, the basic structure of the current clinically used iodine-containing iohexol contrast is 3-acetyl-2,4,6-tribenzoic acid, which is a benzene ring containing 3 iodine. According to different properties, contrast agents can be divided into monomer and dimer contrast agents, ionic and nonionic iodinated contrast, hypertonic, sub-hypertonic and isotonic contrast agents (Table 1).

As one of the most professional contrast media manufacturing companies, Beilu provides glimepiride and contrast dye, iodine based contrast media, iodine containing contrast medium, iohexol iodine and etc.want to know more, contact us.

Repaglinide Tablets(2023年10月04日)

beilupharma — 2023-09-21T11:14:30+0900

https://www.beilupharma.com/products/repaglinide-tablets.html

Repaglinide tablets are non-sulfonylurea insulin secretion agents and are used to treat patients with type 2 diabetes. Repaglinide tablets were listed in China in 2000, and it is a Class B drug in the National Medical Insurance List. Repaglinide tablets have been listed as a drug for diabetic patients with renal insufficiency by many guidelines at home and abroad.

Product name: Repaglinide Tablets

Characteristic: White or off-white tablet

Specification: repaglinide 0.5mg×30 tablets, repaglinide 0.5mg×60 tablets.

Indications：
It is used for type 2 diabetes (non-insulin-dependent) patients whose hyperglycemia cannot be effectively controlled by diet control, weight loss and exercise. When metformin alone cannot effectively control hyperglycemia, Repaglinide tablets can be combined with metformin. Treatment should start from the adjuvant treatment of diet control and exercise to reduce blood sugar during meals.

Specifications of Repaglinide Tablets: 0.5mg

Usage and Dosage，Adverse reactions，Contraindications，Precautions：

Please refer to the package insert.

Medicine Interactions:
Some drugs are known to affect glucose metabolism. Therefore, doctors should consider possible drug interactions.

In vitro studies have shown that the metabolism of Repaglinide is affected by CYP2C8 and CYP3A4. Repaglinide was found to be a substrate for active liver uptake (organic anion transporter OATP1B1).

Storage: Similar to the storage of glimepiride tablets, tab repaglinide should also be shaded, sealed, kept in a dry place.

Packaging:
Aluminum plastic packaging, 15 pills/plate , 2 plates/box; 15 pills/plate, 4 plates/box, 15 pills/plate, 6 plates/box

Shelf life: 24 months

As one of the most professional contrast media manufacturing companies, Beilu provides glimepiride and contrast dye, repaglinide 0.5 tablet, repaglinide 0.5 mg oral tablet, repaglinide tab 0.5 mg, tab repaglinide, repaglinide 0.5 mg tablet, repaglinide 2 mg tablet and etc.want to know more, contact us.

MRI Contrast Media(2023年10月03日)

beilupharma — 2023-09-21T11:13:56+0900

https://www.beilupharma.com/products/mri-contrast-media/

Magnetic resonance imaging Contrast Media (MRI Contrast Media), also called Magnetic resonance imaging Contrast Agents, which is Gadolinium based contrast agent (GBCA), mainly refers to: after being introduced into the body through a certain way (generally intravenous injection), the MRI contrast media can produce more obvious image contrast between interest range and surrounding tissues. Different from the iodinated Contrast Media of CT/X-ray, the contrast media used in mri acts indirectly by affecting the proton relaxation time of the molecule. When entering the blood vessels and tissues of the gadolinium-containing Contrast Media in the body, the mri intravenous contrast Media products can shorten the relaxation time of T1 to enhance image contrast. The gadolinium contrast media for MRI has wide indications, high detection rate, high safety and cost-effectiveness.

Safety of Gadolinium Contrast Media
Acute reactions

contrast agent used in mri possess a very low incidence ( < 2.5 % ) of acute adverse reactions compared to many other drugs. Almost all of their reactions are very mild, the most common are nausea, headache, discomfort at the injection site, vomiting, metallic taste, paresthesia, fever and dizziness.

Chronic ReactionsMRI Contrast Media-Chronic reactions

For more information about different types of mri contrast, please feel free to contact us!

beijing pharmaceuticals, as an excellent face contrast media manufacturer, offers a wide range of face wash for you to choose from.

Ioversol(2023年10月02日)

beilupharma — 2023-09-21T11:13:19+0900

https://www.beilupharma.com/products/ioversol.html

CAS No.: 87771-40-2
Molecular formula: C18H24I3N3O9
Molecular Weight: 807.11
Quality standard: CP, USP
Characteristics: White or almost white powder
Content (HPLC): ≥99.0%
Packing: 25KG, 50KG/drum
Storage: Protected from light, sealed tightly

For more information about ioversol, please feel free to contact us!

Bei lu, as an excellent face contrast media manufacturer, offers a wide range of face wash for you to choose from.

Iopamidol Intermediate (order based) 5-Amino-2,4,6-triiodoisophthalic acid(2023年10月01日)

beilupharma — 2023-09-21T11:12:37+0900

https://www.beilupharma.com/products/iopamidol-intermediate.html

CAS No.: 35453 19 1
Molecular formula: C8H4I3NO4
Molecular weight: 558.84
Quality standard: CP, USP
Content (HPLC): ≥99.0%
Packing: 25KG, 50KG/drum
Storage: Protected from light, sealed tightly

Bei lu, as an excellent face contrast media manufacturer, offers a wide range of face wash for you to choose from.

Knowledge About Non Ionic Contrast Medium(2023年)

beilupharma — 2023-05-24T14:39:07+0900

https://www.beilupharma.com/knowledge-about-non-ionic-contrast-medium.html

Non ionic contrast medium is the second generation of CT contrast medium. For advantages of non ionic contrast media, compared with the first generation of ionic contrast medium, the non ionic contrast medium has greater water solubility. In addition, it does not ionize in water, which has the advantages of low viscosity and low osmotic pressure. Clinically, the incidence and severity of toxic side effects of the non-ionic contrast medium are significantly lower than that of the ionic contrast medium.

1. List of non ionic contrast media

(1) Iohexol: It is a water-soluble non ionic X-ray contrast medium developed in the 1980s. It has the advantages of high water solubility, low viscosity, low osmotic pressure, and low toxicity. It is clinically used in cerebral angiography, coronary angiography, etc.

Iohexol injection has an excellent molecular structure, which can greatly improve user safety and significantly reduce adverse reactions. The iodinated contrast medium has excellent clinical feedback and good imaging effects. In 1998, Beilu's iohexol injection was launched.

(2) Iodophor: It has a better chemical structure than that of the nonionic iodinated contrast, it is considered to be the most hydrophilic non ionic contrast medium and it has a wide range of clinical applications.

(3) Iopamidol: Iopamidol has high iodine content and a good imaging effect. It has low toxicity to blood vessel walls and nerve tissues, and is stable in nature. It is suitable for various types of angiography, enhanced CT scans, urography, myelography, cisternography, etc.

(4) Iopromide: It can be used for enhanced CT examination, digital subtraction angiography (DSA), arteriography, venography, intravenous urography and body cavity angiographies such as arthrography, gastrointestinal angiography and hysterosalpingography.

(5) Iodixanol: Iodixanol visipaque is a new type of isotonic dimer contrast medium. According to the visipaque package insert, iodixanol is a non ionic dimer that contains hexaiodine. It has a common name of iodixanol injection, the trade name of Visipaque.

(6) Iomeprol: Iomeprol has low osmotic pressure, good tolerability, stable performance, and a good imaging effect. It has been widely used and the trade name is Iomeprol.

2.Ionic and nonionic contrast media comparison

Compared with the ionic contrast medium, the advantages of non ionic contrast agents are as follows:

(1) Osmotic pressure: The non ionic contrast medium replaces the carboxyl group attached to the benzene ring in the ionic contrast medium with an amide group. The change in the chemical structure prevents ionization in the solution.

(2) Charge: The non iodinated contrast media does not have the carboxyl group in the molecular structure, and it does not generate charged ions in the aqueous solution. Therefore, the toxic side effects caused by the charge can be eliminated.

(3) Water solubility: The non iodinated contrast medium introduces multiple hydrophilic side chains containing hydroxyl groups into the benzene ring. It has symmetrical spatial distribution and it is surrounded the iodine atom, which can remove the ionic toxicity. Also, the hydroxyl group on the side chain ensures strong water solubility.

(4)Viscosity: Due to the good water solubility, it disperses quickly in the blood and is not easy to aggregate. Therefore, it rarely causes microvascular obstruction.

As one of the most professional contrast media companies, Beijing pharmaceuticals provides glimepiride and contrast dye, gadobutrol injection and etc. Want to know more about difference between ionic and nonionic contrast media, contact us.

Introduction of Intravenous Contrast Media(2023年)

beilupharma — 2023-05-24T14:38:30+0900

https://www.beilupharma.com/introduction-of-intravenous-contrast-media.html

1. Contrast media definition

There are many types of contrast medium in the clinic, and different types of contrast medium will produce different feelings after they are injected into patients. For example, some patients may experience mild pain of the elbow or mild fever during the injection of contrast media products used in enhanced CT.

The injection uses a high-pressure syringe, which can speed up the flow rate of the contrast medium. At the same time, since the contrast medium is viscous, the osmotic pressure is relatively high. Therefore, it will stimulate the blood vessels, such as causing blood vessels to dilate and leading to corresponding symptoms in patients. Some patients may also experience palpitation symptoms such as accelerated heart rate due to excessive tension during the operation.

However, contrast-enhanced ultrasound is better. Most patients have no symptoms when the contrast medium is injected through the elbow veins.

2. Types of contrast media in radiology
(1) Gadopentetate dimethyl meglumine injection/API

Gadopentetate dimethyl meglumine injection is the first gadolinium contrast medium launched by Beijing Beilu Pharmaceutical Co., Ltd. in China in 1992. It has the same safety effects as the original product but is more cost-effective. Beijing Beilu Pharmaceutical Co., Ltd. provides 469mg/ml 10ml, 12ml, 15ml, and 20ml MRI preparations.

(2) Gadobutrol injection/API

Gadobutrol injection is a macrocyclic gadolinium contrast medium, which is more stable than linear cerebrospinal enhanced magnetic resonance imaging (MRI) and enhanced magnetic resonance angiography (CE-MRA), and it is not easy to release gadolinium. Beijing Beilu Pharmaceutical Co., Ltd. provides products with a specification of 604.72mg/ml 7.5m.

(3) Gadolinium dimeglumine injection

Gadopentetate dimeglumine injection is a paramagnetic contrast medium for diagnostic magnetic resonance imaging (MRI) of the liver and central nervous system. Beijing Beilu Pharmaceutical Co., Ltd. provides 10ml specifications.

(4) Ferric ammonium citrate effervescent granules

This oral magnetic resonance contrast medium is one of the different types of MRI contrast that can significantly improve the image quality of MRCP and MRU, and can also be used as a positive contrast medium for the digestive tract. Beijing Beilu Pharmaceutical Co Ltd. offers specifications of 3g: 0.6g (Fe 129mg) and 6g: 1.2g (Fe 258mg).

3. Intravenous contrast media administration

A rapid injection is required with a high-pressure syringe. In general, the injection speed during the inspection is between 2ml~5ml/S. The injection speed of children is between 1.5~3ml/S.

To prevent intravenous contrast medium nephropathy, hydration is usually administered to patients. Oral rehydration is recommended for intravenous users, starting 4-6 hours before the contrast medium injection, and continuing to 24 hours after the contrast medium is used. 100 ml/h water or normal saline should be used by taken orally. It is recommended to use the hydration method of intravenous rehydration if conditions permit.

4. IV Contrast medication contraindications

IV contrast medication contraindications include diabetes, kidney disease, heart disease, asthma, allergies, pheochromocytoma, myasthenia gravis, multiple myeloma, sickle cell disease, etc. However, doctors perform flexible, and sometimes patients with asthma or kidney disease still get injections.

5. Contrast media side effects

The main side effect in the examination of intravascular injection of contrast medium is allergy. However, most people will not have contrast medium allergy. So, there is no need to worry about it. Doctors know the indictions and they will check for allergies before performing an angiogram. Surgery can be considered for varicose intravenous. In addition, a long time of standing or walking should be avoided in daily life.

Introduction of Contrast Medium(2023年)

beilupharma — 2023-05-24T14:37:25+0900

https://www.beilupharma.com/introduction-of-contrast-medium.html

Concept of Contrast Medium

For the purpose of medical imaging, a specific substance is introduced into the human body to change the image contrast of the body's local tissues. This introduced substance is named Contrast Medium.

Classification of Contrast Mediums

According to the influence on the signal, the contrast medium can be divided into positive contrast medium (enhancing the image signal) and negative contrast medium (weakening the image signal).

According to application fields, contrast media products can be divided into X-ray contrast mediums, magnetic resonance contrast mediums, ultrasound contrast mediums and nuclear medicine contrast mediums.

X-ray contrast mediums mainly include barium and iodine contrast mediums. Among them, barium is mainly used for upper gastrointestinal angiography. Iodine contrast mediums include ionic and non-ionic types. Ionic iodine contrast mediums have many adverse reactions due to their chemical structure defects and are currently rarely used in clinical practice; non-ionic iodine contrast mediums are currently the most widely used glimepiride and contrast dye, which is widely used in CT enhancement examination, angiography (including cardiovascular angiography), interventional examination and treatment, urography, various lacunar angiography, and other fields.

In the field of magnetic resonance imaging (MRI), the currently widely used contrast medium in clinical practice is the gadolinium contrast medium (GBCA), which is widely used in enhanced magnetic resonance imaging examination and magnetic resonance angiography (MRA) examination of various organs and tissues.

Founded in 1992, Beilu is mainly engaged in the research & development, production and sales of pharmaceutical products. It is high-tech innovation contrast ltd.

Frequently Asked Questions about Iodine Contrast Users (3)(2023年)

beilupharma — 2023-05-24T14:36:44+0900

https://www.beilupharma.com/frequently-asked-questions-about-iodine-contrast-users-3.html

1. Does the iodine contrast agent need to be preheated? Can the patient benefit from it?
Preheating the iodinated contrast agent before use is recognized as the best method of application. According to clinical observations, preheating makes the patient more comfortable, and can reduce viscosity and the risk of extravasation of Contrast Media. Limited global data show that heating may reduce the incidence of general adverse events.

Before using the different types of iodinated contrast media, it is recommended to heat the contrast agent to 37 degrees Celsius and place it in a thermostat. Because at 37 degrees Celsius, the viscosity of the iodinated contrast agent decreases with the increase in temperature, which not only facilitates the injection of the contrast agent, but also improves the patient's local tolerance.

2. What is the time interval between two injections of iodinated contrast agents?
There should be a time interval between two injections of iodinated contrast agents:

Patients with normal or moderate renal function (GFR>30ml/min/1.73 m2): 75% of iodine can be eliminated in 4 hours after administration. There should be an interval of 4 hours between two injections.

Patients with severely decreased renal function (GFR<30ml/min/1.73 m2): there should be an interval of 48 hours between two injections.

Dialysis patients: if the patient has residual renal function, there should be an interval of 48 hours between the gadobutrol injection and the other injection.

Time interval between simultaneous use of iodine and gadolinium:

Patients with normal or moderate renal function (GFR>30ml/min/1.73 m2): 75% of iodine and gadolinium can be eliminated in 4 hours after administration. There should be an interval of 4 hours between injections of iodine and gadolinium.

Patients with severely decreased renal function (GFR<30ml/min/1.73 m2) or dialysis patients: There should be an interval of 7 days between injections of iodine and gadolinium.

Order of injection of iodine and gadolinium:

For abdominal examination, enhanced CT should be done first, and then enhanced NMR.

For chest and brain examinations, there is no requirement for the order of CT enhancement and NMR enhancement.

3. Is it necessary to stop metformin before using iodinated contrast agents?
Metformin does not increase the risk of acute kidney injury after the injection of contrast agent, but the injury of acute kidney caused by the iodinated contrast agent will contribute to the accumulation of metformin, which may lead to lactic acidosis.

As one of the most professional contrast media companies, beijing beilu pharmaceutical co ltd provides glimepiride and contrast dye, gadopentetate dimeglumine and etc. Want to know more, contact us.

Beilu Pharma's Iohexol Injection Won the Bid in the Fifth round of National Centralized Drug Procurement(2023年)

beilupharma — 2023-05-24T14:35:52+0900

https://www.beilupharma.com/beilu-pharmas-iohexol-injection-won-the-bid-in-the.html

On June 23, Beilu Pharma participated in the fifth round of national centralized drug procurement organized by the National Organization for Centralized Drug Procurement and Use of the Joint Procurement Office.

The company's Iohexol injection (100ml: 35g(I)) was proposed to be selected in the centralized procurement.

Iohexol Injection (100ml: 35g(I)) passed the consistency evaluation of generic products’ quality and efficacy in Apr. 2021. In 2020, the sales revenue from Iohexol Injection was RMB220.96 million, accounting for approximately 26.71% of the operation income of the company.

The relevant information is hereby announced as below:
Generic name of the drugSpecificationIndicationProposed selected priceProcurement lead time
Iohexol Injection100ml:35g(I)X-ray contrast agents It can be used for cardiovascular angiography, arteriography, urography, venography, enhanced CT examinations etc.N/A2 years
Note: The abovementioned product’s proposed winning price and information will be subject to the final announcement issued by the Joint Procurement Office. You can have a look at the iohexol package insert here.

For more information about iohexol price and iohexol injection price, please feel free to contact us!

There are many contrast media companies, but we are one of the best choices for you.

Anti Anxiety Drugs More Effective Than Blood Pressure Medication for Mood-induced Hypertension(2023年)

beilupharma — 2023-05-24T14:34:37+0900

https://www.beilupharma.com/anti-anxiety-drugs-more-effective-than-blood-pressure-medication-for-moodinduced-hypertension.html

Young and middle-aged people face more problems in life, work, and emotion. So they are prone to anxiety, which can lead to high blood pressure. Therefore, it is important to control and relieve the anxiety. If people are stuck in a state of anxiety, then they need to ask for help from doctors. Using anti anxiety drugs under the guidance of doctors can help people quickly get rid of the troubles of the disease.

1. Do anti anxiety drugs lower blood pressure

The nerves that control internal organs in the human body are not controlled by human subjective consciousness and are called autonomic nerves. When we are in tension, fear, anxiety, and other emotions, the autonomic nerves will get excited, which will stimulate the heart rate to increase, and the secretion of hormones such as renin, epinephrine, and norepinephrine in the body will increase, causing arteries to contract and blood pressure to rise.

The peripheral arterioles are more sensitive to these substances, so the increase in low pressure is more obvious, which will affect the peripheral blood supply. Therefore, when we are in a bad mood, we will feel the heart beating wildly, but the hands and feet are cold. And that is because the peripheral arteries contract, which reduces the blood supply to the distal limbs.

2. Take anti anxiety drugs when it is time to take

Secondary hypertension caused by anxiety is also a type of hypertension. If it can't be controlled for a long time, it will also cause damage to the body's organs. In terms of treatment, you can first go through lifestyle improvement, self-suggestion, and other methods to free yourself from anxiety and thus lower blood pressure.

However, if the anxiety symptoms cannot be improved in the short term, antihypertensive treatment is required. However, antihypertensive drugs are only "temporary medical relief" and can only temporarily control blood pressure. To solve the problem, anxiolytic treatment is also needed.

For anti-anxiety treatment, you need to find a professional psychiatrist. If the anxiety symptoms are not serious, you can release the psychological pressure and produce a better therapeutic effect only by "talking" with the doctor. But for severe anxiety symptoms, you need to receive anti anxiety drug treatment.

People with anxiety don't resist medication. With the help of anti anxiety drugs, you can quickly get rid of the anxiety and relieve the symptoms. Although anti anxiety drugs are psychotropic drugs, they can be used under the guidance of a doctor to minimize adverse reactions and dependence. After the anxiety disorder is controlled, the drug can be gradually reduced and stopped without affecting health.

If you need any kinds of contrast medium, please contact us, as a professional contrast media manufacturing companies, Bei lu is willing to offer you high quality products.

Uses of Ferric Ammonium Citrate(2023年)

beilupharma — 2023-05-24T14:34:09+0900

https://www.beilupharma.com/uses-of-ferric-ammonium-citrate.html

Ferric ammonium citrate is classified as a nutritional supplement, and it belongs to iron supplements. It is often used in the production and processing of wheat flour, cookies or baby milk powder. It has the effect of replenishing blood and energy, and it is a common medicine for the treatment of iron deficiency anemia. In addition, it can be used as a food preservative since it has a relatively high copper content. Moreover, it is widely used in some industrial production and chemical plants. More ferric ammonium citrate uses are as follows:

1. Uses of ferric ammonium citrate: Nutritional supplements (iron fortifiers)

Ammonium citrate uses: It can be used for dairy products, wheat flour and toast. Also, it can be added to cookies, baby milk powder, etc. It is not suitable for foods that cannot be colored.

Ferric ammonium citrate is used as a food iron fortifier, and the actual digestion and absorption effect is better than that of inorganic iron. Edible salt and filling sugar are allowed to use in China, and the demand is 4000~8000Mg/kg. The content of cereals and products for the high-speed train (limited to 50g of such food per day) is 1200~1350Mg/kg. Also, the content should be 400~800mg/Kg in dairy products and baby food, 160~330Mg/kg in cereals and related products, 70~140Mg/kg in drinks.

The dark brown one can be used as a blood tonic to treat iron deficiency anemia. And it can be applied as a food preservative, with a copper content of 16.5%-21.2%.

It is usually used in the photographic industry and the production of the pharmaceutical industry, and it also can be used as an anti-caking agent.

3. Ferric ammonium citrate has wide application. How to make it?

It is cultivated by microorganisms, such as the JFM solution that are commonly used in the laboratory modeling of manganese iron bacteria, in which ammonium iron citrate is added. And there are similar solutions that also need to be added to this product.

(1) By dissolving ferric hydroxide with calcobutrol sodium citrate and then mixing it with sodium hydroxide, the substance can be obtained after extracting at 60°C, crystallizing and drying.

(2) The sodium hydroxide and iron hydroxide should be made into an aqueous solution, and then a small amount of iron sulfate is added, and then it is neutralized with sodium citrate to obtain the substance.

Physical and chemical properties:

(1) Characteristics: dark brown or emerald green fish scales or powder shape, with water-absorption.

(2) Iron content: 20.5%-22.5%

(3) Fluoride: ≤0.14%

(4) Potassium thiocyanate: ≤0.5%

(5) Lead salt: ≤0.003%

(6) Arsenic salt: ≤0.005%.

There are two shapes based on the copper content. It is green when the copper content is 14.5% to 16.0%, and it is dark brown when the copper content is 16.5% to 18.5%. Both are complex salts composed of iron, ammonium and sodium citrate, and are easy to deliquescence and mildew.

For more information about types of gadolinium contrast and ferric ammonium citrate for anemia, please feel free to contact us!

To Understand the Development of Iodinated Contrast Agents(2021年)

beilupharma — 2021-12-01T18:24:25+0900

https://www.beilupharma.com/to-understand-the-development-of-iodinated-contrast-agents.html

1. The development history of iodinated contrast agents
Since its development, the iodinated contrast agent has undergone a development process from ionic to non-ionic, from hypertonic to hypotonic and to isotonic:

(3) The isotonic contrast agent was developed to further reduce the osmotic pressure after the hypotonic contrast agent. The isotonic contrast agent is a non-ionic dimer whose osmotic pressure is equal to the plasma osmotic pressure.

2.Types of iodinated Contrast Media
The basic structure of the current clinically used iodine-containing contrast agent is 3-acetyl-2,4,6-tribenzoic acid, which is a benzene ring containing 3 iodine. According to different properties, contrast agents can be divided into monomer and dimer contrast agents, ionic and nonionic iodinat contrasts, hypertonic, sub-hypertonic and isotonic contrast agents (Table 1).

Table 1 Classification and physical and chemical properties of commonly used iodine contrast agents

If you want to know more information about Beilu, please contact us.
We have types of mri contrast for sale, if you have needs, please contact our customer service staffs.

Repaglinide Tablets(2021年)

beilupharma — 2021-12-01T18:23:55+0900

https://www.beilupharma.com/products/repaglinide-tablets.html

Product name: Repaglinide Tablets

Characteristic: White or off-white tablet

Specification: repaglinide 0.5 tablet, repaglinide 0.5mg×60 tablets.

Indications：

It is used for type 2 diabetes (non-insulin-dependent) patients whose hyperglycemia cannot be effectively controlled by diet control, weight loss and exercise. When metformin alone cannot effectively control hyperglycemia, Repaglinide tablets can be combined with metformin. Treatment should start from the adjuvant treatment of diet control and exercise to reduce blood sugar during meals.

Specifications of Repaglinide Tablets: 0.5mg

Usage and Dosage，Adverse reactions，Contraindications，Precautions：

Please refer to the package insert.

Medicine Interactions:

Some drugs are known to affect glucose metabolism. Therefore, doctors should consider possible drug interactions.

In vitro studies have shown that the metabolism of tab repaglinide is affected by CYP2C8 and CYP3A4. Repaglinide was found to be a substrate for active liver uptake (organic anion transporter OATP1B1).

Storage: Similar to the storage of glimepiride tablets, tab repaglinide should also be shaded, sealed, kept in a dry place.

Packaging:

Aluminum plastic packaging, 15 pills/plate , 2 plates/box; 15 pills/plate, 4 plates/box, 15 pills/plate, 6 plates/box

Shelf life: 24 months

Iohexol Injection(2021年)

beilupharma — 2021-12-01T18:23:25+0900

https://www.beilupharma.com/products/iohexol-injection.html

Iohexol Injection is a non-ionic Contrast Media. Compared with a traditional ionic Contrast Media, Iohexol Injection has an excellent molecular structure and it can greatly improve user safety and significantly reduce adverse reactions. The iodinated contrast agent has excellent clinical feedback and good imaging results. In 1998, Iohexol Injection was launched as Beilu's 1st iodinated Contrast Media.

Product name: Iohexol Injection

Generic name: Iohexol Injection

Type: Injectable Contrast Media for CT/X-ray

Ingredients: Iohexol 300

Specification:

(1) 20 ml: 6 gI (2) 50 ml: 15 gI

(3) 75 ml: 22.5 gI (4) 100 ml: 30 gI

(5) 20 ml: 7 gI (6) 50 ml: 17.5 gI

(7) 100 ml: 35 gI

Administration: For injection or oral use of iohexol contrast

Adverse reactions: See the details from the package insert

Shelf life: 36 months

Precautions of Iohexol Injection
General precautions for the use of nonionic-monomer contrast agent:

4. Venous access should be kept smooth throughout the X-ray examination.

5. In the in-vitro tests, the effect of nonionic contrast agents on the coagulation system is lighter than that of ionic contrast agents. During angiography, great care should be taken in the intravascular technical procedures, and the catheter should be irrigated with heparinized saline from time to time to reduce the thrombosis and embolism related to the technical procedures.

9. Preventive actions include:

Identify patients with high-risk factors.

Ensure patients are appropriately hydrated and, if necessary, the infusion may be maintained intravenously prior to examination until the contrast agent is cleared from the kidneys.

Repeat radiographic testing is delayed until renal function returned to the pre-examination level.

10. Observation time:

11. Intraspinal injection:

12. Effects on the ability to drive vehicles and operate machines:

Do not drive a vehicle or operate a machine within 24 hours after intraspinal injection.

13. As with all non-gastrointestinal drugs, this product should be visually inspected before use to check for particulate matter, discoloration and container damage.

This type of Iohexol contrast agent should be drawn into the barrel before use. Each vial is for single use only, and the unused portion should be discarded.
If you want to know more information about Beilu, please visit our website.

Iodixanol Injection(2021年)

beilupharma — 2021-12-01T18:22:52+0900

https://www.beilupharma.com/products/iodixanol-injection.html

Iodixanol visipaque, Iopamidol injection is a CT/X-ray Contrast Media that is isotonic with plasma. It has excellent cardiac safety and renal safety, which is most comfortable to use, especially suitable for high risk patients.

Product name: Iodixanol Injection

Generic name: Iodixanol Injection

Type: Injectable Contrast media for CT/X-ray

Ingredients: Iodixanol

Specification:

(1)100ml-27 gl

(2) 50ml-16 gl

(3)100ml-32 gl

Administration: For Intravascular use only

Adverse reactions: See the details from the package insert

Shelf life: 24 months

Related ct contrast media
Iopamidol Injection
Iohexol Injection

If you want to know more information about Beijing Beilu pharmaceutical co ltd, please visit our website.

Glimepiride Tablets(2021年)

beilupharma — 2021-12-01T18:22:20+0900

https://www.beilupharma.com/products/glimepiride-tablets.html

Glimepiride tablet 1mg is a sulfonylurea hypoglycemic drug that can be used in combination with insulin. In 2001, glimepiride pill (Dibei), as the first hypoglycemic product of Beilu Pharma, was first listed in China and belongs to the second class of national new drugs.

Product name: Glimepiride Tablets
Specifications: glimepiride 1 mg×30 tablets；glimepiride 2mg dosage×15 tablets；glimepiride 2mg×30 tablets

Characteristics: White tablet

Indications :

As one of the contrast media manufacturing companies, our glimepiride tablets are only suitable for type 2 diabetes that cannot fully control blood sugar through diet control, exercise therapy and weight loss.

Usage and Dosage: Please refer to the package insert

Adverse reactions, Contraindications, Precautions: Please refer to the package insert.

Storage: Shade, seal, and keep in a dry place.

Packaging: Aluminum plastic packaging, 15 pills/plate, 1 plate/box; 15 pills/plate, 2 plates/box.

Shelf life: 24 months

Advantages of Glimepiride Tablets
Double effect directly hit the hypoglycemic core

Double effect: glimepiride 1 tablet can promote insulin secretion and improve insulin resistance. At the same time, it can improve the two major pathophysiological abnormalities of insulin secretion and insulin resistance in patients with type 2 diabetes.

Efficiently reduce postprandial blood glucose, fasting blood glucose and glycosylated haemoglobin

Glimepiride tablets monotherapy can comprehensively reduce FPG PPG and HbA1c in newly diagnosed T2DM patients
Combination therapy, such as combined metformin, acarbose, etc., has a more significant overall hypoglycemic effect

Less hypoglycemia, less weight impact, high safety

Short-term treatment, the risk of glimepiride hypoglycemia is only 1/3 of that of Glibenclamide

Long-term treatment, the risk of glimepiride hypoglycemia is only 1/7of that of Glibenclamide

Glimepiride has a small impact on the weight of T2DM patients

Once a day to improve patient compliance

If the patient's compliance is poor, Glimepiride tablets should be selected, once a day.

Gadopentetate Dimeglumine Injection/API(2021年)

beilupharma — 2021-12-01T18:21:43+0900

https://www.beilupharma.com/products/gadopentetate-dimeglumine-injection-api/

Product name: Gadopentetate Dimeglumine Injection

Generic name: Gadopentetate Dimeglumine Injection

Type: Injectable Contrast Media for MRI, Linear Contrast Media

No.1 market share in China

Ingredients: Gadopentetate Dimeglumine

Specification: 10ml:4.69 g; 12ml:5.63 g; 15ml:7.04 g; 20ml:9.38 g

Posology and method of administration: Intravenous injection

Adverse reactions: See the details from the package insert

Shelf life: 36 months

Indication of Gadopentetate Dimegumine Injection
Magnetic resonance imaging of the central nervous system (brain and spinal cord), abdomen, chest, pelvis, limbs and other human organs and tissues.

2. Take care to avoid the extravasation of the gadopentetic acid liquid during injection to prevent tissue pain.

3. The serum iron and bilirubin levels of some patients will increase slightly after medication, but they are asymptomatic and can return to normal within 24 hours.

4. Pregnant women and breastfeeding women should use it with caution. Animal experiments show that a small amount of medicine liquid enters the milk.

5. The effective enhancement time of Magnevist contrast is 45 minutes. MRI examination should be performed immediately after intravenous injection.

6. The remaining medicine liquid after one examination should not be used again.

7. When applying this type of MRI contrast media, follow the relevant safety regulations in magnetic resonance imaging.
8. GBCAs should be used with caution. When plain scan MRI cannot obtain the corresponding vital diagnostic information, GBCAs can be used, and the lowest approved dose is used as much as possible.

9. Gadolinium deposition

The clinical significance of brain gadolinium deposition is unclear.

Gadobutrol Injection/API(2021年)

beilupharma — 2021-12-01T18:21:04+0900

https://www.beilupharma.com/products/gadobutrol-Injection-api.html

Product name: Gadobutrol Injection

Generic name: injection gadobutrol 0.1 ml

Type: Injectable Contrast Media for MRI, Macrocyclic Contrast Media

Ingredients: Gadobutrol

Specification: gadovist 7.5 ml : 4.5354 g

Administration: Intravenous administration only.

Adverse reactions: See the details from the package insert.

Shelf life: 24 months

Indication of Gadopentetate Dimegumine Injection
Magnetic resonance imaging of the central nervous system (brain and spinal cord), abdomen, chest, pelvis, limbs and other human organs and tissues.

2. Pay attention to avoid the extravasation of the liquid during the gadobutrol injection uses so as to prevent tissue pain.

3. The serum iron and bilirubin levels of some patients will increase slightly after medication, but they are asymptomatic and can return to normal within 24 hours.

4. Pregnant women and breastfeeding women should use it with caution. Animal experiments show that a small amount of medicine liquid enters the milk.

5. The effective enhancement time of this product is 45 minutes. MRI examination should be performed immediately after intravenous injection.

6. The remaining medicine liquid after one examination should not be used again.

7. When applying the gadovist doses, follow the relevant safety regulations in magnetic resonance imaging.

8. GBCAs should be used with caution. When plain scan MRI cannot obtain the corresponding vital diagnostic information, GBCAs can be used, and the lowest approved dose is used as much as possible.

9. Gadolinium deposition

The clinical significance of brain gadolinium deposition is unclear.

Ferric Ammonium Citrate Effervescent Granules(2021年)

beilupharma — 2021-12-01T18:20:30+0900

https://www.beilupharma.com/products/ferric-ammonium-citrate-effervescent-granules.html

Ferric Ammonium Citrate Effervescent Granules was launched in 2004. It is an oral magnetic resonance contrast agent/media approved by NMPA in the market, which is a safe and effective double contrast agent with the advantages of convenient use and good safety. This ammonium iron citrate can significantly improve the images quality of MRCP and MRU, and can also be used as a positive contrast agent for the digestive tract.

Product name: Ferric Ammonium Citrate Effervescent Granules

Type: Oral MRI Contrast Media

Ingredients: Ferric ammonium citrate

Specification: 3g: 0.6g（Fe 129mg), 6g: 1.2g（Fe 258mg）

Posology and method of administration: Oral

Adverse reactions: Foreign clinical data reported that after using this MRI contrast medium, 0.1-0.5% of patients has diarrhea, 0.1% had nausea, vomiting, and decreased appetite, and a very small number of patients has stomach discomfort and bloating. All the above symptoms can be eliminated by themselves.

Shelf life: 24 months

Indications of Ferric Ammonium Citrate Effervescent Granules
Used for magnetic resonance abdominal imaging, angiography of the digestive tract (stomach duodenum and jejunum).

Precautions of Ferric Ammonium Citrate Effervescent Granules

1.Use with caution in the following patients: patients with the gastrointestinal tract such as peptic ulcer, ulcerative colitis, local enteritis, etc.

2.The stool appearing black after administration is a normal phenomenon.

3.During the uses of ferric ammonium citrate, false-positive for occult blood may occur.

If you have any doubts about bei lu, please contact us.

CT/X-Ray Contrast Media(2021年)

beilupharma — 2021-12-01T18:19:54+0900

https://www.beilupharma.com/products/ct-x-ray-contrast-media/

The main component of CT/x ray contrast media is iodine. The Iodinated Contrast Media is a colorless, transparent, slightly viscous liquid. At present, the contrast media in ct can be mainly divided into ionic and non-ionic, according to the osmotic pressure can be divided into hypertonic, isotonic and hypotonic. Currently, non-ionic, isotonic or hypotonic Contrast Media are used clinically. When the CT contrast medium is injected, 97% of the contrast media can be directly excreted from the kidneys within 1 day.

Types of ct contrast
Iohexol Injection
Iohexol Injection is non-ionic contrast agent. Compared with traditional ionic contrast agent, Iohexol Injection has the excellent molecular structure, it has greatly improved safety, and significantl...

Iopamidol Injection
Iopamidol Injection is the second-generation non-ionic iodinated contrast media launched in the global market. In 2015, Beilu firstly launched and listed this product in the Chinese market. Product name: Iopam...

Iodixanol Injection
Iodixanol Injection is a ct contrast media that is isotonic with plasma. It has excellent cardiac safety and renal safety, which is most comfortable to use, especially suitable for high risk patients.

Reasonable Use of Iodinated Contrast Agents
Evaluate patient benefits/risks before use

History of allergies: Patients who have previously experienced moderate to severe anaphylactoid reactions to iodinated contrast agents or patients with a history of allergies requiring treatment are at an increased risk of having an allergic reaction to CT scan contrast dye.

Kidney function: iodinated contrast agents can cause acute kidney injury, and patients should be evaluated for related risks before the surgery.

Combination medication: drugs that may increase the risk of adverse reactions to iodinated contrast agents: neuroleptics and antidepressants, interleukin-2, beta-blockers, metformin.

Situations where iodinated contrast agents should be used with caution: lung and heart diseases, catecholamine secreting tumours, pregnant and lactating women, myeloma and macroglobulinemia, myasthenia gravis, homocystinuria.

Contraindication: uncured patients with hyperthyroidism.

Dose limit for iodinated contrast agents used in ct

On the premise of satisfying imaging/diagnosis, the minimum dose of iodinated contrast agents should be used.

For low-risk patients, the total dose of types of contrast agents had better be controlled within 300 ~ 400 ml.

Maximum dose of iodinated radiocontrast dye

Method I *: 5 ml × body weight (kg)/serum creatinine (mg/dl) (not more than 300 ml) [refer to Cigarroa calculation formula]

Method II: 3.7 times creatinine clearance [according to 2011 ACCF/AHAUA/NSTEMI Treatment Guidelines]

For those with severe renal insufficiency, try to choose an imaging method that does not require iodine-based contrast agents or a non-imaging method that can provide sufficient diagnostic information.

Avoid repeated use of the diagnostic dose of an iodinated contrast medium in a short period of time. If repeated use is indeed necessary, it is recommended that the interval between two MRI contrast agent applications be ≥14 days.

Other precautions for the use of iodinated contrast agents

Preheating: Before using an iodinated contrast agent, it is recommended to heat the contrast agent to 37 °C and place it in a thermostat.

Hydration: It is recommended to hydrate patients within 6 to 12 hours before using an iodinated contrast agent to within 24 hours after use. Hydration method: Intra-arterial drug users are advised to receive intravenous rehydration and oral rehydration concomitantly, and oral rehydration is recommended for intravenous drug users.

Stay and observation: After the injection of the iodine-based contrast media, the patient needs to stay and be observed for 30 minutes before leaving the examination room.

Establish an emergency channel: Establish an emergency rapid support mechanism for the rescue of adverse reactions caused by iodinated contrast agents with the emergency room or other clinical related departments to ensure that after an adverse reaction occurs, clinicians can promptly rush to the rescue scene for rescue if necessary.

Prevention and Management of Vascular Extravasation of Iodinated Contrast Agents
Prevention

Choose appropriate blood vessels for venipuncture and operate carefully; when using a high-pressure syringe, choose a puncture needle and catheter that match the injection flow rate; properly fix the puncture needle; communicate with the patient and get cooperation.

Management

Mild extravasation: Most injuries are minor and need no treatment. However, the patient should be instructed to keep observing. If the extravasation worsens, the patient should seek medical attention in time. For individuals with significant pain, common cold and hydropathic compresses can be given locally.

Moderate and severe extravasation: ① raise the affected limb to promote blood return. ② Use 50% magnesium sulfate moisturizing cold compress in the beginning, and after 24-hours change to magnesium sulfate moisturizing hot compress, or use mucopolysaccharide ointment for topical application, or use 0.05% dexamethasone for local hydropathic compress. ③ Those with severe contrast agent extravasation should be given oral dexamethasone 5 mg/time tid for 3 consecutive days on the basis of topical drug use. ④ If necessary, consult a clinician for medication.

Contrast Media Manufacturing Company(2021年)

beilupharma — 2021-12-01T18:19:10+0900

https://www.beilupharma.com/products/contrast-media/

For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as Contrast Agents. As the first contrast media manufacturer in China, Beilu Pharma launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As one of the well-known contrast media manufacturing companies, we could provide a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.

Different types of contrast media in Beilu Pharma
MRI CONTRAST MEDIA
Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast material is more stable and less likely to release gadolinium ions.

CT/X-RAY CONTRAST MEDIA
Iodine-containing Contrast Media is one of the common imaging contrast agents used in radiology diagnosis and interventional therapy. It is also a basic diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated mri contrast media used for cardiovascular system CT and digital subtraction angiography are all water-soluble organic iodinated contrast materials.

Finished Types of Contrast Media

API & Intermediates Types of Contrast Media

The osmotic pressure of normal people is about 290-300mOsm/kg.

Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-2.4.

Three factors of renal injury induced by Contrast Media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage.

Calcobutrol(2021年)

beilupharma — 2021-12-01T18:18:28+0900

https://www.beilupharma.com/products/calcobutrol.html

Calcobutrol
CAS No .: 151878-23-8

Molecular formula: C18H32CaN4O9

Molecular weight: 488.5461

Quality standard: CP

Characteristics: White or off-white powder

Content (HPLC): ≥99.0%

Packing: 2KG/ drum

Storage: Protected from light, sealed tightly

If you want to know more details about Beilu, please visit our website.

As a contrast media manufacturer,we will attempt to provide more high quality products for customers.

Anti-Diabetic Drugs(2021年)

beilupharma — 2021-12-01T18:17:30+0900

https://www.beilupharma.com/products/anti-diabetic-drugs/

The number of people with diabetes rose from 151 million in 2000 to 463 million in 2019; by 2045 this number will rise to 700 million. 1 in 5 of the people who are above 65 years old have diabetes, 1 in 2 people (232 million) with diabetes were undiagnosed, and diabetes caused 4.2 million deaths. Diabetes caused at least USD760 billion dollars in health expenditure in 2019 – 10% of total spending on adults. More than 1.1 million children and adolescents are living with type 1 diabetes, and 374 million people are at increased risk of developing type 2 diabetes.

Diabetes is a chronic disease. Diabetes occurs when the pancreas cannot produce enough insulin or the body cannot effectively use the produced insulin (diabetes is a hormone that regulates blood sugar). High blood sugar or elevated blood sugar is a common result of uncontrolled diabetes. Over time, diabetes can seriously damage many systems of the human body, especially nerves and blood vessels, so the prevention and treatment of diabetes is particularly important in our daily life. In fact, the incidence of diabetes in low- and middle-income countries is rising faster than in high-income countries. As the health problems of diabetes threaten people's lives seriously, the prevention of diabetes and the corresponding antidiabetic medications have also attracted more and more attention. As a professional anti-insulin drugs manufacturer, Beijing Beilu pharmaceutical co ltd can provide you with 2 different types of oral antidiabetic drugs.

List of anti diabetic drugs, types of anti diabetic drugs
Glimepiride Tablets

Glimepiride tablets are sulfonylurea hypoglycemic agents and are suitable for type 2 diabetes. As one of the common antidiabetic drugs, glimepiride tablets have a unique dual mechanism of action, which can promote insulin secretion and improve insulin resistance.

Repaglinide Tablets
Repaglinide tablets are non-sulfonylurea insulin-secreting agents used to treat patients with type 2 diabetes. Repaglinide tablets produced by Beilu Pharma can comprehensively improve the patient's blood glucose control regardless of single-agent or combination therapy.
Antidiabetic drugs list, anti diabetic drugs list, oral antidiabetic drugs list
According to the classification criteria proposed by the international general WHO diabetes expert committee, it is mainly divided into type 1 diabetes, type 2 diabetes and gestational diabetes, the most common type of diabetes in the general population is type 2 diabetes.

Type 1 diabetes is a condition in which your immune system destroys insulin-making cells in your pancreas. The condition is usually diagnosed in children and young people, they mainly rely on exogenous insulin supplementation to maintain their lives.

Type 2 diabetes (previously called non-insulin-dependent or adult-onset diabetes) is caused by the body's inability to use insulin effectively. The vast majority of diabetic patients are type 2 diabetes, this type of diabetes is mainly the result of overweight and lack of physical activity. Until recently, this type of diabetes was seen only in adults but it is now also occurring increasingly frequently in children.

Gestational diabetes is characterized by high blood glucose levels during pregnancy. It may occur at any time during pregnancy (although most likely after week 24) and usually disappears after the pregnancy.

Oral Hypoglycemic Drugs In Patients With Type 2 Diabetes And Chronic Kidney Disease
Chronic kidney disease (CKD) is a group of clinical syndromes characterized by long-term abnormalities of kidney structure and renal function. The incidence is increasing and has become a major global public health problem. Type 2 diabetes is often associated with CKD, which has become one of the main causes of death for diabetic patients in China. Glycemic control is essential to delay the development of early CKD. Oral hypoglycemic drugs are one of the most commonly used hypoglycemic drugs.

There are many types of oral antidiabetic agents, and the pharmacokinetics of various drugs are significantly different. In addition, CKD patients have a decreased ability to clear drugs or their active metabolites excreted by the kidneys. If oral hypoglycemic drugs are used improperly, they will increase the risk of hypoglycemia and other adverse events. Therefore, it is necessary to fully understand the pharmacokinetics and pharmacodynamic characteristics of various antidiabetic oral drugs in clinical work, and make an individualized selection in combination with the patient's renal function to ensure effective hypoglycemia without increasing the risk of hypoglycemia.

Combination of oral hypoglycemic drugs: Metformin is the first choice for monotherapy in most type 2 diabetic patients. Clinically, a combination therapy based on metformin is often selected. If metformin is contraindicated or intolerant, other therapeutic drugs can be selected, such as combination therapy based on α-glycosidase inhibitor or insulin secretagogue (e.g., sulfonylureas, Glinide). In combination therapy, safety should be considered first and the potency ratio should be considered second. Therefore, priority should be given to oral antidiabetic drugs with potential renal benefits and a lower risk of hypoglycemia.

The prognosis of patients with type 2 diabetes and CKD is worse than that of patients with type 2 diabetes or CKD alone. In clinical practice, oral hypoglycemic drugs for patients with type 2 diabetes and CKD should be correctly selected and used in accordance with domestic and foreign diabetes guidelines, especially for patients with renal insufficiency. Once eGFR<60 mL. Min-1. (1.73 m2)-1, the pharmacokinetic and pharmacodynamic characteristics of some oral hypoglycemic drugs will change in these patients, and the risk of hypoglycemia and other adverse reactions will increase significantly. In clinical practice, the blood glucose and renal function of patients with diabetes and CKD should be closely monitored, and the dosage should be adjusted in time to meet the requirements of hierarchical management of the HbA1c target value of diabetic patients and to reduce adverse reactions.

We also have contrast medium for sale, if you have needs, please contact us.

Adverse Drug Reaction (ADR) and Treatment of Major Iodinated Contrast Agents(2021年11月06日)

beilupharma — 2021-11-03T14:15:43+0900

https://www.beilupharma.com/products/ct-x-ray-contrast-media/

With the increasing application of iodinated contrast agents in the diagnosis and treatment of cardiovascular diseases, the adverse reactions and risks caused by iodinated contrast agents have attracted much attention.

1. Injury of acute kidney induced by iodinated contrast agents
The use of iodinated contrast agents can cause an injury called contrast induced acute kidney injury (CIAKI), especially in patients with impaired renal function, patients with endothelial insufficiency, diabetic patients, and patients with insufficient hydration, who are at an increased risk.

CIAKI is only a transient injury in most patients. However, CIAKI may also cause serious consequences: patients with CIAKI have an increased probability of in-hospital complications, including death, and are likely to cause long-term renal insufficiency.

Method of prevention and treatment:

Interventional cardiovascular physicians should pay attention to the following issues when using iodinated contrast agents to reduce the damage of the contrast agents to the patient's kidneys:

(1) Fully assess the patient's risk/benefit ratio before surgery.

(2) Carry out sufficient hydration according to the individual conditions of the patient.

(3) CIAKI is a dose-dependent non-specific adverse reaction based on the patient's basic renal function and overall clinical conditions, and the smallest dose of iodinated contrast agent should be used on the premise that the conditions of imaging and diagnosis are met.

(4) Choose hypotonic or isotonic contrast agents.

2. Allergic reactions to iodinated contrast agents
The common adverse reaction to iodinated contrast agents is skin reaction, mostly acute attack. Mild acute allergic reactions may only manifest as localized urticaria and pruritus. In severe cases, diffuse facial and laryngeal edema, bronchospasm and dyspnea, anaphylactic shock or even respiratory and cardiac arrest may occur. Inappropriate treatment will lead to permanent illness or even death.

Almost all life-threatening adverse reactions of iodinated contrast agents occur within 20 minutes after the injection of the contrast agent. Delayed allergic-like reactions are mostly common skin reactions, most of which occur within 3h to 2d after the injection.

Method of prevention and treatment:

Before using iodinated contrast agents, patients should be selected and prepared according to the general principles of using iodinated contrast agents. The iodinated contrast agent should be fully hydrated and heated to 37°C for use. If the patient has a history of allergy to iodinated contrast agents, non ionic contrast agents with a different composition should be considered.

Make sure that the room should be equipped with first aid equipment and first aid drugs on a regular basis. Medical staff should be familiar with how to treat and rescue patients, and activate the emergency system when necessary, and promptly seek help from relevant departments.

Most of the adverse reactions to non ionic contrast agents are mild and non-life-threatening, which only require observation to dispel the doubts of the patient and symptomatic treatment. Severe and life-threatening adverse reactions are rare and unpredictable. Once an adverse reaction occurs, it is necessary to immediately stop the injection of iodinated contrast agent, and quickly assess the patient's condition and the severity of the adverse reaction, so as to adopt different treatments and measures. Although severe allergic reactions develop rapidly and are dangerous, patients rarely lose their lives if they can be treated in a timely and effective manner.

Beijing Beilu Pharmaceuticals Company Limited is a contrast media manufacturing companies, we provide ct cisternography contrast, contrast material, ct contrast agent and etc.

Congratulations: Beilu Pharma's Iohexol Injection Passed the Consistency Evaluation for Generic Drugs(2021年11月05日)

beilupharma — 2021-11-03T14:15:10+0900

http://beilupharma.com/products/contrast-media/

Recently, Beijing Beilu Pharmaceutical Co., Ltd received the "Drug Supplementary Application Approval Notice" issued by the National Medical Products Administration (NMPA) on Iohexol Injection (100ml:35g, 100ml:30g), and the company's Iohexol Injection passed the quality and efficacy consistency evaluation for generic drugs！

Beilu is a contrast media manufacturing companies, we provide ct cisternography contrast, contrast material, contrast medium and etc.

Frequently Asked Questions about Iodine Contrast Users (3)(2021年11月04日)

beilupharma — 2021-11-03T14:14:43+0900

https://www.beilupharma.com/products/iohexol-injection.html

1. Does the iodinated contrast agent need to be preheated? Can the patient benefit from it?
Preheating the iodinated contrast agent before use is recognized as the best method of application. According to clinical observations, preheating makes the patient more comfortable, and can reduce viscosity and the risk of extravasation of Contrast Media. Limited global data show that heating may reduce the incidence of general adverse events.

Before using the iodinated contrast agent, it is recommended to heat the contrast agent to 37 degrees Celsius and place it in a thermostat. Because at 37 degrees Celsius, the viscosity of the iodinated contrast agent decreases with the increase in temperature, which not only facilitates the injection of the contrast agent, but also improves the patient's local tolerance.

2. What is the time interval between two injections of iodinated contrast agents?
There should be a time interval between two injections of iodinated contrast agents:

Patients with normal or moderate renal function (GFR>30ml/min/1.73 m2): 75% of iodine can be eliminated in 4 hours after administration. There should be an interval of 4 hours between two injections.

Patients with severely decreased renal function (GFR<30ml/min/1.73 m2): there should be an interval of 48 hours between two injections.

Dialysis patients: if the patient has residual renal function, there should be an interval of 48 hours between two injections.

Time interval between simultaneous use of iodine and gadolinium:

Patients with severely decreased renal function (GFR<30ml/min/1.73 m2) or dialysis patients: There should be an interval of 7 days between injections of iodine and gadolinium.

Order of injection of iodine and gadolinium:

For abdominal examination, enhanced CT should be done first, and then enhanced NMR.

For chest and brain examinations, there is no requirement for the order of CT enhancement and NMR enhancement.

Beijing Beilu Pharmaceuticals Company Limited is a contrast media manufacturing companies, we provide ct cisternography contrast, contrast material, ct contrast medium and etc.

Frequently Asked Questions about Iodine Contrast Users (2)(2021年11月24日)

beilupharma — 2021-11-03T14:14:14+0900

https://www.beilupharma.com/products/ct-x-ray-contrast-media/

1. Does the allergy test of iodinated contrast agents need to be done?
The allergy test of iodinated contrast agents cannot reduce the risk of adverse reactions. The guidelines of American College of Radiology (ACR) recommend that the use of iodinated contrast agents for intradermal pre-tests has no predictive value for adverse reactions, and it may be dangerous itself, which is not recommended.

The Chinese Guidelines for the Use of Iodinated Contrast Agents (2nd Edition) suggest that no allergy test of iodine is required unless the product instructions indicate special requirements.

2. Does the iodinated contrast agent need preventive medication?
Before the administration of hypertonic iodinated contrast agents, preoperative prevention of high-risk patients (such as allergies, asthma, cardiovascular disease) can reduce the possibility of adverse events of all severity.

Before the administration of hypotonic iodinated contrast agents, preoperative prevention for high-risk patients can reduce the possibility of mild and overall adverse events.

3.Does the iodinated contrast agent need to be hydrated? How should it proceed?
For high-risk patients to use iodinated contrast agents, hydration is recommended to reduce kidney risk.

The hydration plan recommended by the ACR guidelines: within 6-12 hours before injection of iodinated contrast agents and within 4-12 hours after injection of iodinated contrast agents, 0.9% normal saline should be infused at a rate of 100ml/hour.

The hydration plans recommended in the Chinese Guidelines for the Use of Iodinated Contrast Agents:

Arterial medication: It is recommended to supplement with normal saline 6-12h before contrast agent injection, or 5% glucose plus 154mmol/l sodium bicarbonate solution with drip fluid flow rate≥100ml/l; after contrast agent injection, continuous intravenous rehydration ≥100ml/l for 24 hours

Intravenous medication: Oral rehydration is recommended, starting 4-6 hours before the contrast agent injection and continuing for 24 hours after the contrast agent is used. Clean water or normal saline should be taken orally at the usage amount of 100Ml/H. If conditions permit, it is recommended to use the same hydration method as intra-arterial medication.

Beilu is a contrast media manufacturing companies, we provide ct cisternography contrast, contrast material, gadopentetate dimeglumine and etc.

Frequently Asked Questions about Iodine Contrast Users(1)(2021年11月17日)

beilupharma — 2021-11-03T14:13:46+0900

https://www.beilupharma.com/products/ct-x-ray-contrast-media/

1. Can people at high risk of thyroid toxicity be injected with iodinated contrast agents?
Patients with hyperthyroidism and hypothyroidism need to be closely monitored the changes in thyroid function after receiving an iodinated contrast agents in the body, and be given necessary drug interventions to avoid the risk of thyroid crisis.

Recommendations for the use of iodinated contrast agents in people at high risk of thyroid toxicity:

For patients with obvious hyperthyroidism, iodinated contrast agents should not be given;

If it is suspected that the patient is at risk of hyperthyroidism, testing for thyroid-stimulating hormone (TSH) may be helpful;

For high-risk patients, preventive treatment can be given by an endocrinologist;

High-risk patients should be closely monitored by an endocrinologist after injecting iodinated contrast agent;

High-risk patients should not be given intravenous biliary contrast agents.

2. Can dialysis patients be injected with iodinated contrast agents?
All iodinated contrast agents can be removed by blood or peritoneal dialysis, but there is no evidence showing that hemodialysis can protect patients with impaired renal function from PC-AKI or NSF. All patients should avoid permeation and fluid overload to reduce the impact on new additions.

3. Can patients with pheochromocytoma be injected with iodinated contrast agents?
So far, there is no evidence showing that intravenous iodine contrast agent will increase the risk of hypertensive crisis in patients with pheochromocytoma, so no special preparation is required before intravenous iodine contrast agent is used;

Before iodinated contrast agent is used in arteries, it is recommended to give oral α and β adrenergic blockers under the supervision of the referring doctor.Under such conditions, nonionic iodinated contrast is recommended.

4. Can pregnant and breastfeeding patients be injected with iodinated contrast agents?
All iodinated Contrast ACgents may enter the fetus through the blood-placental barrier. Therefore, pregnant and patients of preparations for pregnant should use iodinated contrast agents with caution. For breastfeeding patients with iodinated contrast agents, only a small amount of iodinated contrast agent is excreted through breast milk and ingested by the baby.

5. Can pediatric patients be injected with iodinated contrast agents?
The dosage of iodinated contrast agent must be adjusted according to the age and weight of the child; when using serum creatinine and other indicators, the normal value corresponding to the specific age must be used; it is recommended to use the revised Schwartz formula to calculate eGFR;

Nonionic iodinated contrast should be used;

Read the instructions of the relevant contrast agent carefully before use. Not all contrast agents are approved for use in children.

Beijing Beilu Pharmaceuticals Company Limited is a contrast media manufacturing companies, we provide ct cisternography contrast, contrast material, gadopentetate dimeglumine and etc.

To Understand the Development of Iodinated Contrast Agents(2021年11月07日)

beilupharma — 2021-11-03T14:12:59+0900

https://www.beilupharma.com/products/iohexol-injection.html

Table 1 Classification and physical and chemical properties of commonly used iodine contrast agents
Structure and classificationCommon nameMolecular massIodine content

( mg /ml)Osmotic pressure
(mOsm/kg H20)
The first generation of hypertonic ionic monomermeglumine
diatrizoate 8093061530
The second generation of sub-hypertonic nonionic monomerIohexol821300 350680 830
Iopamidol777300.370616 796
Iopromide791300 370590 770
Ioverol807320 350710 790
Iomeprol777300 400521 726
Hypotonic ionic dimerioxaglate1270320600
The third generation of isotonic nonionic dimer iodixanol1550320290

Beilu is a contrast media manufacturing companies, we provide ct cisternography contrast, contrast material, mri contrast medium and etc.

Introduction of Contrast Medium(2021年11月03日)

beilupharma — 2021-11-03T14:12:18+0900

https://www.beilupharma.com/products/contrast-media/

Concept of Contrast Medium

Classification of Contrast Mediums
According to the influence on the signal, the contrast medium can be divided into positive contrast medium (enhancing the image signal) and negative contrast medium (weakening the image signal).

According to application fields, imaging agents can be divided into X-ray contrast mediums, magnetic resonance contrast mediums, ultrasound contrast mediums and nuclear medicine contrast mediums.

X-ray contrast mediums mainly include barium and iodine contrast mediums. Among them, barium is mainly used for upper gastrointestinal angiography. Iodine contrast mediums include ionic and non-ionic types. Ionic iodine contrast mediums have many adverse reactions due to their chemical structure defects and are currently rarely used in clinical practice; non-ionic iodine contrast mediums are currently the most widely used clinical contrast mediums, which is widely used in CT enhancement examination, angiography (including cardiovascular angiography), interventional examination and treatment, urography, various lacunar angiography, and other fields.

Beijing Beilu Pharmaceuticals Company Limited is a contrast media manufacturing companies, we provide ct cisternography contrast, contrast material, gadobutrol injection and etc.

Good News: Beilu Pharmaceutical won the 2020 National Adverse Drug Reactions Monitoring and Evaluation Excellent Unit(2021年10月28日)

beilupharma — 2021-09-30T16:29:28+0900

https://www.beilupharma.com/

On March 11th, the National Medical Products Administration (NMPA) issued the “Notice Recognizing Excellent Units in the National Adverse Drug Reactions Monitoring and Evaluation 2020”. In this notice, Beijing Beilu Pharmaceutical Co., Ltd. was awarded the “National Outstanding Unit for the Adverse Drug Reaction Monitoring and Evaluation”.

Here, we would like to express our gratitude and congratulations to all staff of the Pharmacovigilance Department! Wish them could make persistent efforts in the future work and achieve greater results!

Beijing Beilu Pharmaceuticals Company Limited is a professional contrast media companies, we provide ct contrast medium, gadopentetate dimeglumine and etc. Want to know more?contact us now.

Beilu Pharmaceuticals(2021年10月22日)

beilupharma — 2021-09-30T16:27:37+0900

http://beilupharma.com/products/iodixanol-injection.html

Contrast Media
Beilu Pharma offers an extensive range of Contrast Media products for Diagnostic Imaging to help healthcare professionals to make decisive solution through technical imaging data. It concentrates on innovation and quality, constantly upgrading, and aims to be one of the world's most admired brands.

MRI Contrast Media
Gadopentetate Dimeglumine Injection/API
Gadobutrol Injection/API
Gadobenate Dimeglumine Injection
Ferric Ammonium Citrate Effervescent Granules

CT/X-Ray Contrast Media
Iohexol Injection
Iopamidol Injection
Iodixanol Injection

Anti-Diabetic Drugs
The number of people with diabetes rose from 151 million in 2000 to 463 million in 2019; by 2045 this number will rise to 700 million. 1 in 5 of the people who are above 65 years old have diabetes, 1 in 2 people (232 million) with diabetes were undiagnosed, and diabetes caused 4.2 million deaths. Diabetes caused at least USD760 billion dollars in health expenditure in 2019 – 10% of total spending on adults. More than 1.1 million children and adolescents are living with type 1 diabetes, and 374 million people are at increased risk of developing type 2 diabetes.

Diabetes is a chronic disease. Diabetes occurs when the pancreas cannot produce enough insulin or the body cannot effectively use the produced insulin (diabetes is a hormone that regulates blood sugar). High blood sugar or elevated blood sugar is a common result of uncontrolled diabetes. Over time, diabetes can seriously damage many systems of the human body, especially nerves and blood vessels, so the prevention and treatment of diabetes is particularly important in our daily life. In fact, the incidence of diabetes in low- and middle-income countries is rising faster than in high-income countries. As the health problems of diabetes threaten people's lives seriously, the prevention of diabetes and the corresponding antidiabetic medications have also attracted more and more attention. As a professional anti-insulin drugs manufacturer, Beilu Pharma can provide you with 2 different types of high-quality oral antidiabetic drugs.

Anti-Anxiety Drug
How to identify patients with anxiety?
Chief complaints:

Typical somatic symptoms: fatigue, weakness, insomnia, thought slowness, poor appetite

Somatic symptoms A: palpitation, oppression in chest, chest pain, dyspnea, profuse sweating

Somatic symptoms B: headache, dizziness

Somatic symptoms C: abdominal pain, abdominal distension, diarrhea, nausea, dysphagia, weight loss

Somatic symptoms D: dry mouth, constipation, frequent urination, urgent urination, skin flushing or paleness

API

Intermediates

Excipients

Why Choose Beilu
Beilu Pharma is a leader and pioneer in the Contrast Media field in China. It provides a wide range of Contrast Media products for diagnostic imaging and interventional therapy, and it also offers Anti-diabetic and Anti-anxiety medicines to improve the treatment and help healthcare professionals solve problems.

The success of developing and marketing Contrast Media in the local market promotes us to explore overseas market and Beilu Pharma has currently expanded its footprints across Southeast Asia, Africa, Latin America, and Middle East markets. In 2020, Beilu Pharma successfully completed the acquisition of one of the largest Contrast Media API manufacturers-Zhejiang Hichi Pharmaceutical Co., Ltd. and upgraded the strategic layout of industrial chain integration.

Beilu Pharma is open to collaborating with any interested and relevant parties worldwide and we will continue to strive to provide high-quality products at a competitive price.

Beilu is a professional contrast media manufacturer, we provide visipaque contrast media, iodixanol visipaque, visipaque 320 and etc. Want to know more?contact us now.

Jiuwei Zhenxin Granules - Independent Innovation, Classic Inheritance(2021年10月15日)

beilupharma — 2021-09-30T16:27:01+0900

https://www.beilupharma.com/

A famous traditional prescription in Song Dynasty passed down for thousands of years

Jiuwei Zhenxin Granules is a national protection product of Chinese medicine, and it is the first and only pure Chinese medicine preparation approved by NMPA for the treatment of generalized anxiety disorder in China. It has been listed in the national medical insurance catalogue in 2017. As a domestically developed original drug, the brand of Jiuwei Zhenxin has a long history. Besides, the product originated from the famous traditional prescription "Pingbu Zhenxin Granules" in the Song Dynasty, which has a history of nearly one thousand years.

Excellent quality and good reputation

Jiuwei Zhenxin Granules, one fo the patent Chinese anti-anxiety drugs, mainly contain nine Chinese medicinal materials, namely: ginseng, wild jujube seed, schisandra, Poria, Polygala tenuifolia, Corydalis, Asparagus cochinchinensis, Rehmannia glutinosa, and cinnamon. Since its launch, Jiuwei Zhenxin Granules have been recognized and praised by many mental and psychological experts and were awarded the "New Technology and New Product of Zhongguancun Science Park in the 2019 Double Innovation Week" in June 2019.

The same curative effect, lower adverse reactions

Produced by Beilu Pharma, Jiuwei Zhenxin Granules can not only bring very precise curative effects to patients with anxiety disorders but also have a lower incidence of adverse reactions and no risk of addiction and withdrawal.

Six clinical units including Beijing Anding Hospital affiliated with Capital Medical University have conducted multi-centre, randomized, double-blind, double-simulation clinical studies on the safety and effectiveness of Jiuwei Zhenxin Granules and Paroxetine Hydrochloride in the treatment of generalized anxiety disorder. Conclusions show that the clinical efficacy of Jiuwei Zhenxin Granules in the treatment of generalized anxiety disorder is equivalent to that of paroxetine tablets, but the incidence of adverse reactions of Jiuwei Zhenxin Granules is significantly lower than that of paroxetine tablets.

Beijing Beilu Pharmaceuticals Company Limited is a professional contrast media manufacturing companies, we provide ct contrast medium, gadopentetate dimeglumine and etc. Want to know more?contact us now.

Adverse Reaction and Treatment of Contrast Medium(2021年10月08日)

beilupharma — 2021-09-30T16:26:25+0900

https://www.beilupharma.com/products/contrast-media/

Adverse drug reactions refer to harmful reactions that have nothing to do with the purpose of medication or accidentally occur under normal usage and dosage of qualified drugs.

Although the safety of current commonly used clinical contrast mediums, whether it is iodine contrast medium or gadolinium contrast medium, is already very good, adverse reaction still exists. Thus, we must be very vigilant and handle the side effects in time when using them.

The reasons for the adverse reactions of contrast mediums are complex and have not been fully understood so far.

First of all, the structure, composition, technology, and unknown components of the contrast medium are the prerequisites for the adverse reactions of the contrast medium. The improvement of the contrast medium is also in progress. For example, ionic iodine contrast mediums with a higher incidence of adverse reactions have been basically replaced by safer non-ionic iodine contrast mediums. Surely, some detailed mechanisms of adverse reactions have not yet been fully elucidated, and further research and exploration are necessary.

On the other hand, with the same medicine and the same dosage, only a small proportion of contrast medium users will have adverse reactions, indicating that the patient's physical factors play an important role in the mechanism of adverse reactions. Factors related to the patient's physique include (not limited to) age, allergic physique, previous history of adverse reactions to contrast mediums, renal impairment, taking nephrotoxic drugs, dehydration, emotional and psychological factors. These factors are not all contraindications to the use of contrast mediums, but they are reminders that require extra vigilance. Please consult a professional doctor for details.

Adverse reactions can be divided into two categories, one is a toxic reaction, which is dose-dependent; the other is an allergic reaction, which is not dose-dependent.

The general response principle for adverse reactions of contrast mediums is symptomatic treatment. As the contrast-medium-use department, it must be equipped with rescue supplies and drugs. And it should prepare a treatment plan and organize all relevant personnel to conduct adverse reaction treatment drills.

Beilu is a professional contrast media manufacturer, we provide ct contrast medium, mri contrast medium and etc. Want to know more?contact us now.

Introduction of Contrast Medium(2021年10月01日)

beilupharma — 2021-09-30T16:25:27+0900

https://www.beilupharma.com/products/contrast-media/

Concept of Contrast Medium

Classification of Contrast Mediums

According to the influence on the signal, the contrast medium can be divided into positive contrast medium (enhancing the image signal) and negative contrast medium (weakening the image signal).

According to application fields, imaging agents can be divided into X-ray contrast mediums, magnetic resonance contrast mediums, ultrasound contrast mediums and nuclear medicine contrast mediums.

X-ray contrast mediums mainly include barium and iodine contrast mediums. Among them, barium is mainly used for upper gastrointestinal angiography. Iodine contrast mediums include ionic and non-ionic types. Ionic iodine contrast mediums have many adverse reactions due to their chemical structure defects and are currently rarely used in clinical practice; non-ionic iodine contrast mediums are currently the most widely used clinical contrast mediums, which is widely used in CT enhancement examination, angiography (including cardiovascular angiography), interventional examination and treatment, urography, various lacunar angiography, and other fields.

Beijing Beilu Pharmaceuticals Company Limited is a professional contrast media companies, we provide ct contrast medium, gadobutrol injection and etc. Want to know more?contact us now.