Hefei KS-V Peptide Biological Technology Co., Ltd.

INTRODUCTION TO SBDD(2023年05月07日)

difficultpeptide — 2023-04-23T11:09:02+0900

https://www.difficultpeptide.com/introduction-to-sbdd.html

Ⅰ.What is SBDD?

Structure based drug design (SBDD) is a drug design method based on molecular recognition from the three-dimensional structure of ligands and targets. According to drugs and their targets, such as receptors, enzymes, ion channels, nucleic acids, antigens and viruses, we can find and design reasonable drug molecules.

Generally, the steps of SBDD include protein structure preparation, binding site recognition, ligand library preparation, docking and scoring function.

Target is the prerequisite of drug design. The selection of reasonable drug target directly determines the success or failure of drug development. The three-dimensional structure of the target can often be obtained by computer model methods such as X-ray crystallography, multi-dimensional nuclear magnetic resonance or homologous protein structure prediction. Secondly, the interaction model between drug and receptor is measured by experimental means or studied by computational method, and the rational drug design is carried out on this basis; In addition to considering the structural characteristics of drugs and receptors, it is also necessary to consider the influence of factors such as drug solubility, toxicity and metabolic process. Reasonable drug design usually requires 10-15 cycles to find the "most suitable" drug molecules.

Ⅱ. Advantages and disadvantages of SBDD Technology Platform

2. Deficiency: This design requires a complete and clear three-dimensional structure of the target; it only considers the binding strength of the drug and the receptor, and cannot predict the efficacy of the drug; the speed is slow.

If you need any kinds of peptides synthesis, please contact us, as the peptide pharmaceutical companies, KS-V peptide is willing to offer you high quality products.

Gene to Structure(2023年05月06日)

difficultpeptide — 2023-04-23T11:08:35+0900

https://www.difficultpeptide.com/gene-to-structure/

As a professional peptide company in China, we can provide innovative drugs from gene to protein, from gene to structure, from structure to lead compound to new drug preclinical candidate drug and other services, and efficiently promote the discovery of innovative drug candidates.

OUR CAPABILITIES IN GENE TO STRUCTURE
● Construct design with all commercially available vectors
● Multiple tags, inserts, mutations, deletes, and multi-parallel construct design
● High capacity protein expression in E Coli, Insect cells, and mammalian cells
● Automatic protein purification by AKTA.
● Double stand DNA purification
● Post-treatment of protein for crystallization: Protein refolding, dephosphorylation, and deglycosylation
● 13C, 2H, and 15N Labeled proteins for NMR
● Membrane protein purification from over 70 GPCR stable cell lines, 50 human gene targets.
● Endotoxin-free protein purification (Final endotoxin as low as 0.1EU/mg)

●Off-the-Shelf protein production service

OUR ADVANTAGES IN GENE TO STRUCTURE
Our Advantages in Gene to Structure
We have several methods which are used to determine the structure of a biomacromolecule, including Nuclear Magnetic Resonance (NMR) spectroscopy and Cryogenic Electron Microscopy (cryo-EM).

We have the most complete and state-of-the-art platform and professional knowledge cluster.

After finishing the study, KS-V peptide company will provide you with the confidential structural determination report:

–A report of the process of the different phase

–Structure confirmation

For more information about g2s services and custom synthesis china, please feel free to contact us!

Drug Discovery(2023年05月05日)

difficultpeptide — 2023-04-23T11:08:05+0900

https://www.difficultpeptide.com/drug-discovery/

With a team of experienced experts, advanced research equipment, and proprietary methods, KS-V Peptides provides a one-stop service for your early peptide drug discovery and accelerates your drug development process.

For CRO and drug discovery services, we are open to flexible business arrangements for our contract research and drug discovery services, which can include: Peptide Library Construction; PDC Drugs and Structure Confirmation.

KS-V Peptides committed to providing reliable contract research services to our client's drug discovery processes. We can also provide you with quality peptide APIs based on the above services. Comprehensive drug development services are designed to reduce your cost and time and help you discover a list of high-quality peptide drugs.

What is peptide medications?
Peptide drug refers to a peptide having a specific therapeutic effect extracted by chemical synthesis genetic recombination or animal or plant and is a specific application of the peptide in the field of medicine. The biological activity of the peptide is extensive and important, and it can be widely applied to the endocrine system, the immune system, the digestive system, the cardiovascular system, the blood system, the musculoskeletal system, etc.

As drugs, peptides have many advantages, such as wide indications, high safety, and significant efficacy. With the continuous development of biotechnology, more and more peptide medications have been developed and applied in clinical practice.

For more information about peptide drugs list, please feel free to contact us!

If you need any kinds of peptide service, please contact us, as one of the peptide synthesis suppliers, KS-V peptide is willing to offer you high quality products.

Custom Peptide Synthesis(2023年05月04日)

difficultpeptide — 2023-04-23T11:07:36+0900

https://www.difficultpeptide.com/custom-peptide-synthesis/

KS-V Peptide has always been committed to the research and development of advanced peptide synthesis technology. We have owned a number of peptide synthetics technologies and have been one of the top suppliers of custom peptide synthesis services in China today. Comprehensive quality control management and strict testing services ensure the high-quality delivery of each peptide. Our customers have covered world-renowned universities, research institutes, and biomedical companies.

CUSTOM PEPTIDE SYNTHESIS SERVICES WE CAN PROVIDE

Peptide display library/array synthesis long peptide synthesis

Large-scale peptide synthesis

D-type amino acid peptide synthesis service

Recombinant peptide synthesis

Peptide synthesis

Glycopeptide Synthesis Service. Oligopeptide synthesis

Bicyclic peptide synthesis service

A variety of antigen peptides and dendrimers

METHODS OF PEPTIDE SYNTHESIS
We can provide peptide synthesis from mg to kg of high-quality compound synthesis, such as synthesis of APl intermediates, reference

compounds, metabolites, and impurities expansion to non-GLP drug substances, as well as the development and synthesis of PROTAC drug molecules.

Main Methods:

1. Solid-phase peptide synthesis is used to prepare biologically active peptides, including long peptides, difficult peptides, and hydrophobic peptides.

2. Biosynthesis provides different types of peptide modifications and customized peptides for diagnostic and therapeutic applications.

SERVICE CONTENT OF OUR PEPTIDE SYNTHESIS
Free peptide consultation and design
Custom peptides according to your requirements such as ultra-long peptide.
Peptide modification
Mass spectrometry and HPLC chromatogram confirm purity and characteristics
Provided as a lyophilized powder

QUALITY CONTROL OF OUR CUSTOM PEPTIDE SYNTHESIS
After peptide synthetics, each type of peptide synthesized is routinely analyzed by LC-MS, MALD-MSor HPLC to confirm the quality of the customized peptide.

Mass spectrometry

All peptides were analyzed by MALDl-MS to determine the molecular weight of the synthetic peptides.

High-performance liquid chromatography

MALDI is an excellent method to determine the presence of the desired product but it is not sufficient to determine purity. Therefore, all non-crude peptides must be analyzed by reversed-phase HPLC(RP-HPLC) to determine the purity. Other QC analyses can be performed, such as amino acid analysis, NMR, CE, and peptide content determination to confirm the quality of customized peptides.

Other quality control (optional)

Chromatography (HPLC,TLC,GC，IC)

Chromatography combined with mass spectrometry (LC-MS/ESI)Metal analysis(AAS, ICP，ICP-MS)

Titration (acid-base titration, Karl Fischer titration)

Spectroscopy (Uv-Vis, IR, NMR)

Elemental analysis

Amino acid analysis

Peptide sequencing

WHY CHOOSE PEPTIDE SYNTHESIS SERVICE of KS-V PEPTIDE
As a professional provider of peptides synthesis in China, KS-V Peptide aims to be the top reliable peptide synthesis company by offering excellent peptide synthesis services that featured by the following advantages:
Consistent result: the success rate of delivering high-quality peptides stored in argon stabilizers> 99%;
Not limited to short or long peptides, chemical or recombinant peptide technology;
Lots of conjugation, modification, and labeling;
Quality control: all peptides are analyzed by MS and HPLCFast turnaround;
Free peptide design tool and competitive custom peptide synthesis price.

As a peptide synthesis supplier, we provide peptide library services, peptide toxin, peptide service, peptide analysis services, custom large scale peptide synthesis, etc. Contact us to know custom peptide synthesis price or custom peptides synthesis applications.

KS-V PEPTIDE CULTURE(2023年05月03日)

difficultpeptide — 2023-04-23T11:07:09+0900

https://www.difficultpeptide.com/company-culture.html

KS-V Peptide Culture
Company Mission

KSVP focuses on high-quality peptide products and services and is committed to promoting the research and development of innovative peptide and protein drugs.

Company Vision

Establish a standard system for the industrialization of the custom peptide synthesis service

Promote the development of domestic innovative peptide drugs

Build International Peptide Center in Hefei

Values

Safety first, quality first, efficient innovation, serving the society

For more information about custom peptide manufacturing and epigenetic histone modification, please feel free to contact us!

PEPTIDE SERVICES CENTER(2023年05月02日)

difficultpeptide — 2023-04-23T11:06:39+0900

https://www.difficultpeptide.com/820959-17-9_sp

ABOUT KS-V PEPTIDE
MORE ABOUT KS-V PEPTIDE

ABOUT KS-V PEPTIDE
Hefei KS-V Peptide is a pre-clinical new drug research and development CRO company based on structure and chemistry and it has grown into one of the leading and full-fledged peptide manufacturers and peptide synthesis suppliers in China. With peptides as the core, it provides innovative peptide and protein products and services for global pharmaceutical companies, biotechnology companies, and scientific research institute.

Besides, as one of the professional custom peptide synthesis companies in China, KS-V Peptide has been specialized in providing customized synthesis services of difficult peptides, including Toxins and Analogues, Ubiquitins and Ubiquitin Probes, Post-translational Histones and other peptide manufacturing, APIs and process optimization of the pharmaceutical peptide.

For more information about kurtoxin and epigenetics histone modification, please feel free to contact us!

WHAT DOES UBIQUITIN DO?(2023年05月01日)

difficultpeptide — 2023-04-23T11:05:54+0900

https://www.difficultpeptide.com/1052-what-is-the-function-of-ubiquitination.html

Ubiquitin is a highly conserved protein widely found in nuclear cells. It cooperates with ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and ubiquitin ligase (E3) to achieve ubiquitination and modification of specific proteins, and finally achieves the removal of aging, damaged and misfolded proteins, and is conducive to maintaining The normal physiological function of cells plays a very important role. In addition, some ubiquitination reactions can also achieve functional regulation independent of protein degradation.

As a custom peptide company, we provide pre clinical trials, peptide toxin, peptide service, na+ channel blocker, multi ubiquitination, different types of ubiquitination, etc. Want to know ubiquitination function and what is the role of ubiquitin.

UB AMC(2023年03月03日)

difficultpeptide — 2023-03-03T16:25:22+0900

https://www.difficultpeptide.com/products/ub-amc/

Ubiquitin AMC is prepared by the C-terminal derivatization of ubiquitin with 7-amino-4-methylcoumarin.

SPECIFICATION OF UB AMC
CATU1010
Product NameUb-AMC
Purity≥95% by HPLC analysis
AppearanceLyophilized powder
UsageResearch use only
StorageShipping at room temperature.
Upon delivery aliquot.
Stored at -20°C or -80°C.
Avoid freeze/thaw cycle.
IntroductionUbiquitin-AMC is a fluorogenic substrate for a wide range of deubiquitinating enzymes (DUBs), including ubiquitin C-terminal hydrolases (UCHs) and ubiquitin-specific proteases (USPs). It is a particularly useful reagent for the study of deubiquitinating activity where detection sensitivity or continuous monitoring of activity is essential.

APPLICATION OF UB AMC
Can be used for the following applications:

1. Substrate for deubiquitinylating enzyme activity assays.

2. Identification/confirmation of enzyme deubiquitinylation activity.

3. Investigation of deconjugating enzyme-substrate specificity in comparison with alternative UBL substrates.

There are many peptide manufacturing companies in China, but we are one of the best choices for you.

SYN AKE(2023年03月03日)

difficultpeptide — 2023-03-03T16:24:50+0900

https://www.difficultpeptide.com/products/syn-ake/

Tripeptide-3, also known as dipeptide diaminobutyryl benzyl amide diacetate or SYN®-AKE, mimics the action of wagering-1, a peptide found in venom.

SPECIFICATION OF SYN AKE
Purity(HPLC)≥99%
Content≥75%
Acetic Acid≤15%
Moisture≤8%
20% below market price
10+kg per month
Fast delivery

APPLICATION OF SYN AKE
Product NameSYN-AKE / Dipeptide Diaminobutyroyl Benzylamide
CAS No823202-99-9Molecular FormulaC19H29N5O3(C2H4O2)2
Sequencebeta-Ala-Pro-Dab-NHBzlMolecular Weight495.569g/mol
Package1g, 10g, 100g, 500g, customizableAppearanceWhite Freeze-dried Powder
ApplicationCosmetic raw materialsStorage2～8℃

Efficacy and Mechanism of Action:

Tripeptide-3 (sequence: beta-Ala-Pro-Dab-NHBn-2-Acetate), also known as dipeptide diaminobutyryl benzylamine diacetate or syn ake peptide, mimics the action of wagering-1, a peptide found in venom. V snake Tropidolaemus wagleri. Tripeptide-3 acts on the postsynaptic membrane and is a reversible antagonist of the acetylcholine receptor.

Hefei KS-V Peptide is a pre-clinical new drug research and development CRO company based on structure and chemistry and it has grown into one of the leading and full-fledged difficult peptide manufacturers and peptide synthesis suppliers in China. With peptides as the core, it provides innovative peptide and protein products and services for global pharmaceutical companies, biotechnology companies, and scientific research institute.

If you want to know more details of modification of histones, please visit our website.

SYN AKE(2023年03月)

difficultpeptide — 2023-03-03T16:23:20+0900

https://www.difficultpeptide.com/products/syn-ake/

Tripeptide-3, also known as dipeptide diaminobutyryl benzyl amide diacetate or SYN®-AKE, mimics the action of wagering-1, a peptide found in venom.

SPECIFICATION OF SYN AKE
Purity(HPLC)≥99%
Content≥75%
Acetic Acid≤15%
Moisture≤8%
20% below market price
10+kg per month
Fast delivery

Efficacy and Mechanism of Action:

If you want to know more details of modification of histones, please visit our website.

SHK TOXIN(2023年03月03日)

difficultpeptide — 2023-03-03T16:22:51+0900

https://www.difficultpeptide.com/products/shk-toxin/

Various KV K+ channels. Stichodactyla Toxin blocks KV1.3, KV1.1, KV1.4, and KV1.6 at subnanomolar concentrations and KV3.2 channels at 1000-fold higher concentration than that required to inhibit KV1.3 channels.

SPECIFICATION OF SHK TOXIN
CATK1010-V
CAS NO.172450-46-3
Product NameShK Toxin
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight4055 Da
Molecular formulaC169H274N54O48S7
SourceSynthetic peptide
StorageShipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceRSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC (Disulfide bonds between Cys3-Cys35, Cys12-Cys28, and Cys17-Cys32)

APPLICATION OF SHK TOXIN
ShK toxin is a cysteine-rich 35-residue protein ion-channel ligand isolated from the sea anemone Stichodactyla helianthus.

Hefei KS-V Peptide is a pre-clinical new drug research and development CRO company based on structure and chemistry and it has grown into one of the leading and full-fledged peptide manufacturers and custom peptide library suppliers in China. With peptides as the core, it provides innovative peptide and protein products and services for global pharmaceutical companies, biological technology companies, and scientific research institute.

SEMAGLUTIDE AND IMPURITY(2023年03月03日)

difficultpeptide — 2023-03-03T16:22:25+0900

https://www.difficultpeptide.com/products/semaglutide-and-impurity/

Semaglutide Peptide for Sale

"Natural semaglutide is a recombinant DNA produced polypeptide analog of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents."

SPECIFICATION OF SEMAGLUTIDE AND IMPURITY
CAS NO.910463-68-2
Product NameSemaglutide
Purity(HPLC)98%
AppearanceWhite powder
Molecular weight4114 g/mol
Molecular formulaC187H291N45O59

APPLICATION OF SEMAGLUTIDE AND IMPURITY
Indication:
Semaglutide is a recombinant DNA-produced polypeptide analog of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents.

Efficacy and mechanism of action
long-acting human glucagon-like peptide-1 (GLP-1) analog developed by Novo Nordisk was subcutaneously injected once a week. It was approved by the FDA for marketing in December 2017 under the trade name Ozempic.

Note: All products of Hefei KS-V Peptide CDMO are for scientific research only, not for clinical trials.

Hefei KS-V Peptide is a pre-clinical new drug research and development CRO company based on structure and chemistry and it has grown into one of the leading and full-fledged peptide manufacturers and custom peptide synthesis china suppliers in China. With peptides as the core, it provides innovative peptide and protein products and services for global pharmaceutical companies, biotechnology companies, and scientific research institute.

PSALMOTOXIN 1(2023年03月03日)

difficultpeptide — 2023-03-03T16:21:06+0900

https://www.difficultpeptide.com/products/psalmotoxin-1/

ASIC1a channels, Psalmotoxin-1 inhibits cation currents mediated by acid-sensing ion channels (ASIC1a)1,2

SPECIFICATION OF PSALMOTOXIN 1
CATO1120-V
CAS NO./
Product NamePsalmotoxin 1
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight4689.5 Da
Molecular formulaC200H312N62O57S6
SourceSynthetic peptide
StorageShipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceEDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT(Disulfide bonds between Cys3-Cys18, Cys10-Cys23, and Cys17-Cys33)

APPLICATION OF PSALMOTOXIN 1
Psalmotoxin 1 (a component of the venom of a West Indies tarantula) is a 40-amino acid peptide synthesis china that inhibits cation currents mediated by acid-sensing ion channels (ASIC).

More details of toxicological analysis, please visit our website.

PROTOXIN II(2023年03月03日)

difficultpeptide — 2023-03-03T16:20:40+0900

https://www.difficultpeptide.com/products/protoxin-ii/

NaV channels and T-type Ca2+ channels, Protx-II inhibits NaV channels1. Protx-II could also modulate T-type Ca2+ channels at higher concentrations2.

SPECIFICATION OF PROTOXIN II
CATN1030-V
CAS NO.165168-50-3
Product NameProtoxin II
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight4054.85 Da
Molecular formulaC169H274N54O48S7
SourceSynthetic peptide
StorageShipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceRSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC (Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32)

APPLICATION OF PROTOXIN II
Protoxin II, an inhibitory cystine knot toxin from the tarantula Thrixopelma pruriens, inhibits voltage-gated sodium channels.

As one of peptide synthesis companies, we can offer kinds of related products for sale, anything you need, please leave us a message.

More kinds of peptide service, please visit our website.

PLTX II(2023年03月03日)

difficultpeptide — 2023-03-03T16:20:14+0900

https://www.difficultpeptide.com/products/pltx-ii/

SNX482
Selective, irreversible presynaptic voltage-gated Ca2+ channel blocker. Potent neurotoxin. Selective, irreversible presynaptic voltage-gated Ca2+ channel blocker. Potent neurotoxin. Selective exocytosis inhibitor. Shows insecticidal effects in vivo.

SPECIFICATION OF PLTX II
CATC1100-V
CAS NO./
Product NamePLTX-II (PLTX-II, presynaptic voltage-gated Ca2+ channel blocker)
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight5108.73
Molecular formulaC208H313N61O70S10
SourceSynthetic peptide
StorageShipped at room temperature. The product, as supplied, can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceADCSATGDTCDHTKKCCDDCYTCRCGTPWGANCRCDYYKARCDT (Modifications: C-terminal amide; Thr-44 = O-palmitoyl; Disulfide bonds: 3-17, 10-23, 16-35, 20-42, 25-33)

APPLICATION OF PLTX II
PLTX II, a presynaptic calcium channel blocker in Drosophila isolated from the plectrums spider venom, is a 44-residue peptide containing ten Cys residues and an O-palmitoylated threonine amide at the carboxy-terminus

If you want to know more kinds of custom polypeptides, please visit our website.

More applications of peptides synthesis, please visit contact us.

PLECANATIDE(2023年03月03日)

difficultpeptide — 2023-03-03T16:19:20+0900

https://www.difficultpeptide.com/products/plecanatide/

Polypeptides is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for the treatment of chronic constipation and irritable bowel syndrome.

SPECIFICATION OF PLECANATIDE
CAS NO.467426-54-6
Product NamePlecanatide
Purity(HPLC)98%
AppearanceWhite powder
Molecular weight1681.9 g/mol
Molecular formulaC65H104N18O26S4
Storage-20℃

APPLICATION OF PLECANATIDE
Indication:
Plecanatide tablets is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for the treatment of chronic constipation and irritable bowel syndrome.

Note: All products of Hefei KS V Peptide are for scientific research only, not for clinical trials.

As a peptide company, we can offer kinds of related products for sale, if you have needs, please contact us.

Kaliotoxin(2023年01月19日)

difficultpeptide — 2023-01-05T12:05:03+0900

https://www.difficultpeptide.com/products/kaliotoxin/

SPECIFICATION OF KALIOTOXIN

CATK1070-V
CAS NO.145199-73-1
Product NameKaliotoxin
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight4149.89 Da
Molecular formulaC171H283N55O49S6
SourceSynthetic route peptide
StorageShipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceGVEINVKCSGSPQCLKPCKDAGMRFGKCMNRKCHCTPK (Disulfide bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35)

APPLICATION OF KALIOTOXIN
Kaliotoxin (KTX), a specific blocker of potassium channels, exerts various toxic effects due to its action on the central nervous system.

Hefei KS-V Peptide is a pre-clinical new drug research and development CRO company based on structure and chemistry and it has grown into one of the leading and full-fledged peptide manufacturers and peptide custom synthesis china suppliers in China. With peptides as the core, it provides innovative peptide and protein products and services for global pharmaceutical companies, biotechnology companies, and scientific research institute.

Iberiotoxin(2023年01月17日)

difficultpeptide — 2023-01-05T12:04:36+0900

https://www.difficultpeptide.com/products/iberiotoxin/

IBERIOTOXIN
KCa1.1 K+ channels, Iberiotoxin is a potent selective blocker of the high conductance Ca2+-activated K+ channels (maxi-K).

SPECIFICATION OF IBERIOTOXIN

CATK1060-V
CAS NO.129203-60-7
Product NameIberiotoxin
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight4230.9 Da
Molecular formulaC179H276N50O56S7
SourceSynthetic peptide
StorageShipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceZFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. Z = Pyrrolidone carboxylic acid)

APPLICATION OF IBERIOTOXIN
Iberiotoxin (IbTX) is a remarkably selective alpha-K toxin peptide (alpha-KTx) inhibitor of the maxi-K channel.

Hefei KS-V peptide biological technology Co.,Ltd. is a high-tech enterprise focusing on Peptide CDMO drug discovery and innovative technology services. The founding team is from Tsinghua University and University of Science and Technology of China, and the management team has rich experience in innovative drug R&D and technical services. With peptide as the core, the company has built a core peptide seed bank, including DNA coding and combinatorial chemical peptide library, phage display bicyclic peptide library, etc. , in vitro functional screening (especially membrane protein targets), structure analysis, pharmacological efficacy, pharmacokinetics and other core technology platforms, can provide comprehensive services for pharmaceutical companies, biotechnology companies, and scientific research units.

Huwentoxin Iv(2023年01月15日)

difficultpeptide — 2023-01-05T12:04:07+0900

https://www.difficultpeptide.com/products/huwentoxin-iv/

HUWENTOXIN IV
TTX-sensitive Na+ channels, Huwentoxin-IV specifically inhibits the neuronal tetrodotoxin-sensitive (TTX-S) voltage-gated Na+ channel (IC50 = 30 nM) in adult rat dorsal root ganglion neurons, while having no significant effect on the tetrodotoxin-resistant (TTX-R) voltage-gated Na+ channel1-3.

SPECIFICATION OF HUWENTOXIN IV

CATN1020-V
CAS NO.526224-73-7
Product Namehuwentoxin IV
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight4107.20 Da
Molecular formulaC174H277N51O52S6
SourceSynthetic peptide
StorageShipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI (Disulfide bonds: Cys2-Cys17, Cys9-Cys24, and Cys16-Cys31)

APPLICATION OF HUWENTOXIN IV
Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule

As the best peptide supplier, we will do our best to provide more types of related products for sale, anything you need, please contact us.

If you want to know more details of epigenetic histone modification, please visit our website.

H4K8ac(2023年01月13日)

difficultpeptide — 2023-01-05T12:03:40+0900

https://www.difficultpeptide.com/products/h4k8ac/

H4K8AC
Synthesized histone H4 peptide corresponding to residues within 1-102 of human histone H4 with acetylation K8 modification.

SPECIFICATION OF H4K8AC

CATH4201
Product NameHistone H4-K8ac
Purity≥95% by HPLC analysis
AppearanceWhite powder
UsageResearch use only
StorageShipping at room temperature.
Upon delivery aliquot.
Stored at -20°C or -80°C.
Avoid freeze/thaw cycle.
SequenceSGRGKGGK(ac)GL GKGGAKRHRK VLRDNIQGIT KPAIRRLARR GGVKRISGLI YEETRGVLKV FLENVIRDAV TYTEHAKRKT VTAMDVVYAL KRQGRTLYGF GG

APPLICATION OF H4K8AC
H4K8ac, representing an epigenetic modification to the DNA packaging protein histone H4, is a mark indicating the acetylation at the 8th lysine residue of the histone H4 protein. It has been implicated in the prevalence of malaria.

As a chinese peptide company, we will do our best to meet all the needs of customers.

If you want to know more about chemical structure identification, please visit our website.

H4K20ac(2023年01月11日)

difficultpeptide — 2023-01-05T12:03:13+0900

https://www.difficultpeptide.com/products/h4k20ac/

H4K20AC
Synthesized histone H4 peptide corresponding to residues within 1-102 of human histone H4 with acetylation K20 modification.

SPECIFICATION OF H4K20AC

CATH4204
Product NameHistone H4-K20ac
Purity≥95% by HPLC analysis
AppearanceWhite powder
UsageResearch use only
StorageShipping at room temperature.
Upon delivery aliquot.
Stored at -20°C or -80°C.
Avoid freeze/thaw cycle.
SequenceSGRGKGGKGL GKGGAKRHRK(ac) VLRDNIQGIT KPAIRRLARR GGVKRISGLI YEETRGVLKV FLENVIRDAV TYTEHAKRKT VTAMDVVYAL KRQGRTLYGF GG

APPLICATION OF H4K20AC
Modification of histones are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H4K20ac is associated with gene repression in human cells. Unlike H3K9me3, a constitutive heterochromatin mark, H4K20ac was less associated with TSSs of completely silenced genes (those with no mRNA expression), suggesting that H4K20ac may play a role in repressing transcribed genes rather than in assisting with heterochromatin formation to induce a fully silent state, possibly preventing methylation on the same residue.

Hefei KS-V Peptide is a pre-clinical new drug research and development CRO company based on structure and chemistry and it has grown into one of the leading and full-fledged peptide manufacturers and peptide suppliers in China. With peptides as the core, it provides innovative peptide and protein products and services for global pharmaceutical companies, biotechnology companies, and scientific research institute.

H4K16ac(2023年01月09日)

difficultpeptide — 2023-01-05T12:02:46+0900

https://www.difficultpeptide.com/products/h4k16ac/

SPECIFICATION OF H4K16AC

CATH4203
Product NameHistone H4-K16ac
Purity≥95% by HPLC analysis
AppearanceWhite powder
UsageResearch use only
StorageShipping at room temperature.
Upon delivery aliquot.
Stored at -20°C or -80°C.
Avoid freeze/thaw cycle.
SequenceSGRGKGGKGL GKGGAK(ac)RHRK VLRDNIQGIT KPAIRRLARR GGVKRISGLI YEETRGVLKV FLENVIRDAV TYTEHAKRKT VTAMDVVYAL KRQGRTLYGF GG

APPLICATION OF H4K16AC
H4K16ac antibody is an epigenetic modification to the DNA packaging protein Histone H4. It is a mark that indicates the acetylation at the 16th lysine residue of the histone H4 protein. H4K16ac is unusual in that it has both transcriptional activation AND repression activities. The loss of H4K20me3 along with a reduction of H4K16ac is a strong indicator of cancer.

Acetylation of histone H4 on lysine 16 (H4K16ac) is especially important for chromatin structure and function in a variety of eukaryotes and is catalyzed by specific histone lysine acetyltransferases (HATs). H4K16 is particularly interesting because this is the only acetylatable site of the H4 N-terminal tail, and can influence the formation of a compact higher-order chromatin structure. Hypoacetylation of H4K16 appears to cause delayed recruitment of DNA repair proteins to sites of DNA damage in a mouse model of the premature aging syndrome Hutchinson Gilford progeria. H4K16ac also has roles in transcriptional activation and the maintenance of euchromatin.

As one of the best peptide synthesis companies in China, KS-V Peptide has been specialized in providing customized synthesis services of difficult peptides, including Toxins and Analogues, Ubiquitins and Ubiquitin Probes, Post-translational Histones and other peptide manufacturing, APIs and process optimization of the pharmaceutical peptide.

H4K12ac(2023年01月07日)

difficultpeptide — 2023-01-05T12:02:20+0900

https://www.difficultpeptide.com/products/h4k12ac/

SPECIFICATION OF H4K12AC

CATH4202
Product NameHistone H4-K12ac
Purity≥95% by HPLC analysis
AppearanceWhite powder
UsageResearch use only
StorageShipping at room temperature.
Upon delivery aliquot.
Stored at -20°C or -80°C.
Avoid freeze/thaw cycle.
SequenceSGRGKGGKGL GK(ac)GGAKRHRK VLRDNIQGIT KPAIRRLARR GGVKRISGLI YEETRGVLKV FLENVIRDAV TYTEHAKRKT VTAMDVVYAL KRQGRTLYGF GG

APPLICATION OF H4K12AC
H4K12ac is an epigenetic modification to the DNA packaging protein histone H4. It is a mark that indicates the acetylation at the 12th lysine residue of the histone H4 protein. H4K12ac is involved in learning and memory. It is possible that restoring this modification could reduce age-related decline in memory.

As one of reputable peptide companies, we can offer kinds of peptides synthesis for sale, anything you need, please leave us a message.

Common Histone H4(2023年01月05日)

difficultpeptide — 2023-01-05T12:01:55+0900

https://www.difficultpeptide.com/products/h4/

SPECIFICATION OF HISTONE H4

CATH4100
Product NameHistone H4
Purity≥95% by HPLC analysis
AppearanceWhite powder
UsageResearch use only
StorageShipping at room temperature.
Upon delivery aliquot.
Stored at -20°C or -80°C.
Avoid freeze/thaw cycle.
SequenceSGRGKGGKGL GKGGAKRHRK VLRDNIQGIT KPAIRRLARR GGVKRISGLI YEETRGVLKV FLENVIRDAV TYTEHAKRKT VTAMDVVYAL KRQGRTLYGF GG

APPLICATION OF HISTONE H4
Histone H4 is one of the five main human histone h4 protein involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the 'beads on a string' organization. Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long-term regulation of genes.

Histone H4 is a 102 to 135 amino acid protein which shares a structural motif, known as the histone fold, formed from three a-helices connected by two loops. Histone proteins H3 and H4 bind to form an H3-H4 dimer, two of these H3-H4 dimers combine to form a tetramer. This tetramer further combines with two H2a-H2b dimers to form the compact Histone octamer core.

Histone methylation occurs on arginine, lysine and histidine amino acids residues. Mono-, di- or tri-methylation has been discovered on histone H2A, H3 and H4. Histone methylation has been associated with various cellular functions such as transcription, DNA replication, and DNA damage response including repair, heterochromatin formation, and somatic cell reprogramming. Also methylation of histone H4 by PRMT1 was sufficient to permit subsequent acetylation on the N-terminal tail. However, acetylation of H4 inhibits its methylation by PRMT1, such as H4K20me2.

Acetylation of histones is thought to relax condensed heterochromatin as the negative charge of acetyl groups can repel the DNA phosphate backbone charges, thus reducing the histone binding affinity for DNA. We can provide H4K5ac, H4K8ac, H4K12ac, H4K16ac, H4K20ac.

If you want to know more details of histone h4 peptide, please visit our website.

As one of custom peptide synthesis companies, we can offer kinds of related products for sale, anything you need, please leave us a message.

INTRODUCTION TO SBDD(2022年)

difficultpeptide — 2022-06-09T10:52:58+0900

https://www.difficultpeptide.com/introduction-to-sbdd.html

Ⅰ.What is SBDD?

Generally, the steps of SBDD include protein structure preparation, binding site recognition, ligand library preparation, docking and scoring function.

Ⅱ. Advantages and disadvantages of SBDD Technology Platform

1.Advantages: low screening cost. Candidate drugs can be obtained from a small number of compounds; It can significantly improve the hit rate of drug discovery; It can directly predict the drug receptor binding energy.
2.
3.Deficiency: This design requires a complete and clear three-dimensional structure of the target; it only considers the binding strength of the drug and the receptor, and cannot predict the efficacy of the drug; the speed is slow.

As one of the most professional peptide manufacturing companies, we provide custom peptide synthesis china, g2s services, histone h3, etc. Contact us to know more.

GENE TO STRUCTURE(2022年)

difficultpeptide — 2022-06-09T10:52:36+0900

https://www.difficultpeptide.com/gene-to-structure/

We have the most complete and state-of-the-art platform and professional knowledge cluster.

After finishing the study, KS-V peptide company will provide you with the confidential structural determination report:

–A report of the process of the different phase

–Structure confirmation

As one of the most professional peptide pharmaceutical companies, we provide custom peptide synthesis china, g2s services, epigenetic histone modification, etc. Contact us to know more.

PEPTIDE DRUG DISCOVERY(2022年)

difficultpeptide — 2022-06-09T10:52:15+0900

https://www.difficultpeptide.com/drug-discovery/

What is Peptide Drug?
Peptide drug refers to a peptide having a specific therapeutic effect extracted by chemical synthesis genetic recombination or animal or plant and is a specific application of the peptide in the field of medicine. The biological activity of the peptide is extensive and important, and it can be widely applied to the endocrine system, the immune system, the digestive system, the cardiovascular system, the blood system, the musculoskeletal system, etc.

As one of the most professional peptide synthesis suppliers, we provide custom peptide synthesis china, custom large scale peptide synthesis, epigenetics histone modification, etc. Contact us to know more.

CUSTOM PEPTIDE SYNTHESIS(2022年)

difficultpeptide — 2022-06-09T10:51:52+0900

https://www.difficultpeptide.com/custom-peptide-synthesis/

KS-V Peptide has always been committed to the research and development of advanced peptide synthesis technology. We have owned a number of peptide synthesis technologies and have been one of the top suppliers of custom peptide synthesis services in China today. Comprehensive quality control management and strict testing services ensure the high-quality delivery of each peptide. Our customers have covered world-renowned universities, research institutes, and biomedical companies.

CUSTOM PEPTIDE SYNTHESIS SERVICES WE CAN PROVIDE

Peptide display library/array synthesis long peptide synthesis

Large-scale peptide synthesis

D-type amino acid peptide synthesis service

Recombinant peptide synthesis

Peptide synthesis

Glycopeptide Synthesis Service. Oligopeptide synthesis

Bicyclic peptide synthesis service

A variety of antigen peptides and dendrimers

METHODS OF PEPTIDE SYNTHESIS
We can provide peptide synthesis from mg to kg of high-quality compound synthesis, such as synthesis of APl intermediates, reference

compounds, metabolites, and impurities expansion to non-GLP drug substances, as well as the development and synthesis of PROTAC drug molecules.

Main Methods:

1. Solid-phase peptide synthesis is used to prepare biologically active peptides, including long peptides, difficult peptides, and hydrophobic peptides.

2. Biosynthesis provides different types of peptide modifications and customized peptides for diagnostic and therapeutic applications.

SERVICE CONTENT OF OUR PEPTIDE SYNTHESIS
Free peptide consultation and design

Custom peptides according to your requirements such as ultra-long peptide.

Peptide modification

Mass spectrometry and HPLC chromatogram confirm purity and characteristics

Provided as a lyophilized powder

Mass spectrometry

All peptides were analyzed by MALDl-MS to determine the molecular weight of the synthetic peptides.

High-performance liquid chromatography

WHY CHOOSE PEPTIDE SYNTHESIS SERVICE of KS-V PEPTIDE
As a professional provider of peptide synthesis in China, KS-V Peptide aims to be the top reliable peptide synthesis company by offering excellent peptide synthesis services that featured by the following advantages:

Consistent result: the success rate of delivering high-quality peptides stored in argon stabilizers> 99%;

Not limited to short or long peptides, chemical or recombinant peptide technology;

Lots of conjugation, modification, and labeling;

Quality control: all peptides are analyzed by MS and HPLCFast turnaround;

Free peptide design tool and competitive custom peptide synthesis price.

Hefei KS-V Peptide Biological Technology Co., Ltd. (KS-V Peptide) is a professional peptide synthesis supplier, we provide custom peptide synthesis china, custom large scale peptide synthesis, peptide analysis services, peptide modification services, peptides synthesis, etc. Contact us to know custom peptides synthesis applications or more.

KSVP CULTURE(2022年)

difficultpeptide — 2022-06-09T10:51:27+0900

https://www.difficultpeptide.com/company-culture.html

KSVP CULTURE

Company Mission

KSV Peptide focuses on high-quality peptide products and services and is committed to promoting the research and development of innovative peptide and protein drugs.

Company Vision

Establish a standard system for the industrialization of the custom peptide synthesis service

Promote the development of domestic innovative peptide drugs

Build International Peptide Center in Hefei

Values

Safety first, quality first, efficient innovation, serving the society

Hefei KS-V Peptide Biological Technology Co., Ltd. (KS-V Peptide) is a professional custom peptide company, we provide custom peptide synthesis china, peptide service, etc. Contact us to know more.

ABOUT KS-V PEPTIDE(2022年)

difficultpeptide — 2022-06-09T10:51:01+0900

https://www.difficultpeptide.com/

Hefei KS-V Peptide is a pre-clinical new drug research and development CRO company based on structure and chemistry and it has grown into one of the leading and full-fledged peptide manufacturers and peptide synthesis suppliers in China. With peptides as the core, it provides innovative peptide and protein products and services for global pharmaceutical companies, biotechnology companies, and scientific research institute.

Hefei KS-V Peptide Biological Technology Co., Ltd. (KS-V Peptide) is a professional peptide synthesis supplier, we provide custom peptide synthesis china, na+ channel blocker, peptide service, kurtoxin, histone h4, etc. Contact us to know more.

WHAT DOES UBIQUITIN DO?(2022年)

difficultpeptide — 2022-06-09T10:50:37+0900

https://www.difficultpeptide.com/1052-what-is-the-function-of-ubiquitination.html

Ubiquitin is a highly conserved protein widely found in nuclear cells. It cooperates with ubiquitin activating enzyme (E1), multi ubiquitination conjugating enzyme (E2), and ubiquitin ligase (E3) to achieve ubiquitination and modification of specific proteins, and finally achieves the removal of aging, damaged and misfolded proteins, and is conducive to maintaining The normal physiological function of cells plays a very important role. In addition, some ubiquitination reactions can also achieve functional regulation independent of protein degradation.

Want to know what is the role of ubiquitin and types of ubiquitination, please contact us.

Hefei KS-V Peptide Biological Technology Co., Ltd. (KS-V Peptide) is a professional peptide synthesis supplier, we provide peptide synthesis china, na+ channel blocker, peptide service, semaglutide for sale, etc. Contact us to know ubiquitination function or more.