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Shanghai China, February 1, 2021— STA Pharmaceutical Co., Ltd., (“WuXi STA”) , a leading Contract Development and Manufacturing Organization, WuXi Biologics ("WuXi Bio") (2269.HK), a global company with leading open-access biologics technology platforms and Antengene Corporation Limited ("Antengene", SEHK: 6996.HK), a leading innovative biopharmaceutical company dedicated to discovering, developing and commercializing global first-in-class and/or best-in-class therapeutics in hematology and oncology, today announced a strategic collaboration to accelerate the development and manufacturing of antibody-drug conjugate (ADC) drug candidates in Antengen’s pipeline.

Antengene has invested in the ADC field for a long time, dedicating to discovery, development and commercialization of innovative therapeutics. Through this collaboration, WuXi STA and WuXi Biologics will provide services for the process development, scale-up, and GMP manufacturing of ADC drug intermediates. Antengene will focus on the discovery and development of monoclonal antibody, the core element of the ADC drug development. WuXi STA will focus on the GMP manufacturing of linkers and payloads while WuXi Biologics will provide process development for monoclonal antibody and the biological conjugation as well as the subsequent GMP manufacture. All three parties will work closely to leverage the resources and technological capabilities, with the goal to accelerating the development of ADCs for the benefit of patients.

Dr. Jay Mei, Founder, Chairman and CEO of Antengene, commented: “We are pleased to form a long-term strategic partnership with WuXi STA and WuXi Biologics. It has long been Antengene’s strategic imperative to establish our own in-house discovery capabilities, and we started our early discovery programs through the Antengene New Drug Discovery Center. Through strategic alliances and further integrating our clinical development, regulatory, and early discovery teams, we are rapidly advancing our in-house discovery programs. We believe that this collaboration will allow us to build an even stronger capabilities in ADC field by combining deep expertise from the three companies. I am confident that together we can bring our ADC pipeline forward much faster that will ultimately bring benefit to patients in need.”

Dr. Minzhang Chen, CEO of WuXi STA, commented: “We are delighted to strengthen our strategic cooperation with Antengene. I am confident that WuXi STA's leading capability and capacity for high potency API and conjugation chemistry for novel molecular modalities such as ADCs, along with our high quality standards in meeting global regulatory requirements, will provide the strongest support for ADC linker and payload development and manufacturing. We will continue to leverage our ‘end-to-end’ novel molecular modality platform to empower more partners to accelerate their development pathway to market for the benefit of global patients.”

Dr. Chris Chen, CEO of WuXi Biologics, said: “We are glad to expand our strategic collaboration with Antengene to advance its ADC program into clinical stage, leveraging our integrated biologics platforms, unparalleled capacity and world-class quality system. WuXi Biologics will continue to increase capabilities and capacities to enable global partners as they develop next-generation biologics such as ADCs for the benefit of patients worldwide. ”

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