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Montelukast is a selective leukotriene receptor antagonist used orally for the treatment of asthma and allergic rhinitis. It is also a powerful oral preparation that can significantly improve cis-inflammatory indicators. Biochemical and pharmacological bioassays have shown that montelukast sodium is highly affinity and selective for CysLT1 receptors (compared to other pharmacologically important airway receptors such as prostaglandins, cholinergics, and β-adrenergic receptors). Montelukast efficiently inhibits the physiological effects of LTC4, LTD4 and LTE4 binding to CysLT1 receptors without any receptor agonist activity. A second type of cysteylleukotriene receptor (CysLT2) is present in the lungs, but may be confined to blood vessels.

Montelukast sodium is suitable for the prevention and long-term treatment of asthma in adults and children, including the prevention of asthma symptoms during the day and at night, the treatment of asthma patients sensitive to aspirin, and the prevention of exercise-induced bronchoconstriction, it can also be used to relieve seasonal allergic rhinitis symptoms in patients aged 15 years and older who are ineffective or intolerant to other treatments.

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