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A ca tumour marker is a chemical substance that reflects the presence of a Tumor. It is present in malignant tumour cells, not in normal adult tissues, and substances abnormally produced by malignant tumour cells or by the host's response to tumour stimulation created it.

Their presence or quantitative changes can indicate the nature of the tumour to understand the histogenesis, cell differentiation, and cell function of the tumour.

Detection of tumour markers has the following functions:

Early detection of tumour;

Tumour census and screening;

Diagnosis, differential diagnosis and staging of tumours;

Monitoring the efficacy of surgery, chemotherapy and radiotherapy for tumour patients;

Indicators of tumour recurrence;

Prognosis of tumour;

Looking for the primary foci of metastases of unknown origin.

Types Of Tumor Marker
CA50
Name
Mouse anti-human CA50 mAb
Humanized anti-human CA50 mAb

CA125
Name
Mouse anti-human CA125 mAb
Humanized anti-human CA125 mAb

CA242
Name
Mouse anti-human CA242 mAb
Humanized anti-human CA242 mAb

CA15-3
Name
Mouse anti-human CA15-3 mAb
Humanized anti-human CA15-3 mAb

CA19-9
Name
Mouse anti-human CA19-9 mAb
Humanized anti-human CA19-9 mAb

CA72-4
Name
Mouse anti-human CA72-4 mAb
Humanized anti-human CA72-4 mAb

Pepsinogens I (PGI)
Name
PGI antigen
Anti-human PGI monoclonal antibody

Human Epididymis 4 (HE4)

Name
Recombinant human HE4 protein (Prokaryotic HE4 full-length protein)

Prostate-Specific Antigen (PSA)
Name
Mouse anti-human PSA mAb
Humanized anti-human PSA mAb
Mouse anti-human free PSA mAb
Prostate-Specific Antigen (Eukaryotic expression)

Squamous Cell Carcinoma (SCC)
Name
Mouse anti-human SCC mAb
Humanized anti-human SCC mAb
Prokaryotic expression antigen (full length)

Neuron-Specific Enolase (NSE)
Name
Mouse anti-human NSE mAb
Recombinant human neuron-specific enolase (Prokaryotic NSE protein full length)

Cytokeratin 19 Fragment (CYFRA21-1)
Name
Mouse anti-human CYFRA21-1 mAb
Humanized anti-human CYFRA21-1 mAb

Human Progastrin-releasing Peptide (ProGRP)

Name
Mouse anti-human ProGRP mAb
Humanized anti-human ProGRP mAb
Recombinant human proGRP 31-98 fragment (Prokaryotic expression)

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA II)

Name
Mouse anti-human PIVKA-II mAb
Humanized anti-human PIVKA-II mAb
Human PIVKA II protein prokaryotic expression (N-terminal fragment)
Tumor Antigens
Tumor antigens generally refer to new or overexpressed antigenic substances during the occurrence and development of tumors.

The possible mechanisms for the body to produce tumor antigens are: 1) gene mutation; 2) the activation of genes that were not expressed initially during the process of cell carcinogenesis; 3) abnormalities in some aspects of the antigen synthesis process (such as abnormal glycosylation leading to the production of unique protein degradation products) ); abnormal and ectopic expression of antigens or differentiation antigens during embryonic stage; ⑤ overexpression of specific gene products, significantly signal transduction molecules; ⑥ expression of exogenous genes (such as viral genes).

Cancer Antigen
According to the specificity of cancer antigens, cancer antigens are divided into (1) Tumor-specific antigens (2) Tumor-associated antigens.

Tumor-specific antigen (TSA) is a neoantigen-specific to tumor cells or exists only in specific but not in normal cells.

Tumor-associated antigen (TAA) refers to antigens peculiar to non-tumor cells and exist in normal cells and other tissues. Still, their content is significantly increased when cells become cancerous.

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