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https://www.sekbio.com/procalcitonin-pct.html

Procalcitonin is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It arises once preprocalcitonin is cleaved by endopeptidase.

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Current targeting conventional markers(C-reactive protein, white blood cell, tumor necrosis factor-α, interleukins, etc.) are non-specific for diagnosing sepsis. Procalcitonin (PCT), a member of the calcitonin superfamily, could be a critical tool for diagnosing sepsis. But to distinguish between bacterial versus viral infections, procalcitonin alone may not be effective. Rapid elevation in the concentration of procalcitonin and other newly emerging biomarkers during disease and its correlation with severity of illness makes it an ideal biomarker for bacterial infection. Besides this, the procalcitonin levels can be used to monitor response to antimicrobial therapy, diagnose secondary inflammations, diagnose renal involvement in pediatric urinary tract infection, etc.

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