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NaV channels and T-type Ca2+ channels, Protx-II inhibits NaV channels1. Protx-II could also modulate T-type Ca2+ channels at higher concentrations2.

SPECIFICATION OF PROTOXIN II
CATN1030-V
CAS NO.165168-50-3
Product NameProtoxin II
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight4054.85 Da
Molecular formulaC169H274N54O48S7
SourceSynthetic peptide
StorageShipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceRSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC (Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32)

APPLICATION OF PROTOXIN II
Protoxin II, an inhibitory cystine knot toxin from the tarantula Thrixopelma pruriens, inhibits voltage-gated sodium channels.

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