Ethyl difluoroacetate organic intermediate
(2022年05月12日)Ethyl difluoroacetate is an important organic intermediate, which is mainly used in medicine, pesticide, organic synthesis and other fields.
There are many downstream pharmaceutical products of ethyl difluoroacetate, and the large-scale production of ethyl difluoroacetate has a broad market prospect in the in-depth research on pharmacology, safety and clinical treatment of most of them.
Uses Ethyl difluoroacetate is mainly used in pharmaceutical intermediates.
Preparation methods at present, the preparation of fluorine of ethyl acetate method is more, there are the following method Chemicalbook: method 1, EP0694523 released a two fluorine preparation of ethyl acetate, the method is under the catalyst, tetrafluoroethylene and methanol addition, four fluorine ethane synthesis of methoxyl group, methoxy four fluorine oxide catalytic cracking are two fluorine acetyl fluoride, ethyl acetate and ethanol esterification and get two fluorine.
Chemical properties Boiling point 98℃.
A colorless transparent liquid with unpleasant odor, slightly soluble in water, miscible with ethanol, ethyl ether and other organic compounds.
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