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Cytokeratins are epithelial markers whose expression don't lose during malignant transformation. CYFRA21 1 is a cytokeratin-19 fragment soluble in serum and can use as a circulating tumour marker. Although expressed in all body tissues, it is significant in the lung, particularly lung cancer tissues. CYFRA21 1 is a sensitive and specific tumour marker of non-small-cell lung cancer (NSCLC), especially the squamous cell subtype.It also reflects the extent of the disease and has an independent prognostic role along with performance status and disease stage in NSCLC.In addition, detection of serum CYFRA 21–1 allows for identifying high-risk patients that may benefit from adjuvant chemotherapy and enables the early detection of progressive disease in recurrent NSCLC.Additionally, CYFRA 21–1 describe as a valuable marker for oesophagal squamous cell carcinoma and therapy monitoring of bladder cancer.

CYFRA21-1 IntroIn malignant epithelial cells, the activated protease accelerates the degradation of the cells so that a large number of cytokeratin 19 fragments are released into the blood, and the soluble pieces can specifically bind to the two monoclonal antibodies KS19.1 and BM19.21, so it is called CYFRA21 -1. In malignant lung cancer tissues, CYFRA21-1 is abundant, especially in lung squamous cell carcinoma. The molecular weight of CYFRA21-1 is about 30,000 Da.The serum level of CYFRA21-1 was not related to age, gender, smoking, and pregnancy. Pneumonia, tuberculosis, bronchitis, bronchial asthma, emphysema, and other diseases generally do not cause CYFRA21-1 elevation. Benign liver disease renal failure can cause a slight increase, but rarely more than 10ng/ml. Cytokeratin Tumor Marker Cytokeratin (CK) classifies intermediate filaments that constitute the cytoskeleton. There are many types, among which the cytokeratin 19 (CK19) fragment CYFRA21-1 is the most important in the diagnosis of malignant tumors; the release of CK19 increases when cells become cancerous. , After CK19 is degraded by protease or apoptosis, its fragments are released into the blood. The expression of different keratin fragments has the specificity of tissue distribution, squamous cell carcinoma and adenocarcinoma mainly express CK19, small cell undifferentiated carcinoma mainly express CK18 or only a tiny amount of CK19. CYFRA21-1 is a fragment of cytokeratin 19. It is composed of two monoclonal antibodies to cytokeratin 19, the main component of the cell structure. It is mainly found in the cytoplasm of tumor cells of epithelial origin, such as lung cancer and esophageal cancer. All lung squamous cell carcinomas express CYFRA21-1. When the cells become cancerous, the release of CYFRA21-1 due to the necrolysis of tumor cells increases the blood content, reflecting the prognosis and therapeutic efficacy of the disease. Since the serum product of CK19, CYFRA21-1, is a non-organ-specific tumor marker, comprehensive analysis of clinical data should be combined in clinical application to make a more accurate judgment.

SEKBIO Incorporated is a prestigious biotech developer and manufacturer, based in the vibrant city of Shenzhen. We pride ourselves on being your trusted partner in the field of Immunodiagnostic reagents, delivering innovative solutions to meet your needs. Our diverse range of cutting-edge immunoassay platforms includes fully automatic chemiluminescence immunoassay, fluorescent immunoassay, and LFA, ensuring accurate and reliable results.