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Ubiquitin is a highly conserved protein widely found in nuclear cells. It cooperates with ubiquitin activating enzyme (E1), multi ubiquitination conjugating enzyme (E2), and ubiquitin ligase (E3) to achieve ubiquitination and modification of specific proteins, and finally achieves the removal of aging, damaged and misfolded proteins, and is conducive to maintaining The normal physiological function of cells plays a very important role. In addition, some ubiquitination reactions can also achieve functional regulation independent of protein degradation.

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