Huwentoxin Iv

(2023年01月15日)

https://www.difficultpeptide.com/products/huwentoxin-iv/

HUWENTOXIN IV
TTX-sensitive Na+ channels, Huwentoxin-IV specifically inhibits the neuronal tetrodotoxin-sensitive (TTX-S) voltage-gated Na+ channel (IC50 = 30 nM) in adult rat dorsal root ganglion neurons, while having no significant effect on the tetrodotoxin-resistant (TTX-R) voltage-gated Na+ channel1-3.

SPECIFICATION OF HUWENTOXIN IV

CATN1020-V
CAS NO.526224-73-7
Product Namehuwentoxin IV
Purity> 98%
Form/StateLyophilized powder
SolubilitySoluble in water
Molecular weight4107.20 Da
Molecular formulaC174H277N51O52S6
SourceSynthetic peptide
StorageShipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutionsUp to two weeks at 4°C or three months at -20°C.
SequenceECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI (Disulfide bonds: Cys2-Cys17, Cys9-Cys24, and Cys16-Cys31)

APPLICATION OF HUWENTOXIN IV
Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule

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