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The Beneficial Effects Of Stem Cell for Diabetes
Stem cell therapy can improve pancreatic islets function, hepatic glucose, and lipid metabolism while lowering blood sugar.

Clinical research and applications have shown that through stem cells therapy, about 65% of the patients are no longer dependent on insulin or oral drug to treat diabetes, and over 90% of patients reported reduced a dosage of insulin or oral drug or changed from insulin injection to oral drug. Collectively, stem cell therapy greatly diminished the onset and development of diabetes complications.

The era of clinical stem cell treatment for diabetes has come!
Reduction of diabetes medication intake

Maintenance of normal blood sugar levels

Restoration of the sensitivity of peripheral tissue to insulin and increase of insulin levels

Prevention and improvement of related diabetic foot symptoms

Reduction of hepatocyte lipid-related lesions

Improvement in the condition of the arterial walls and reduction of hyperinsulinemia and atherosclerosis

Prevention or reversion of certain complications of diabetes, such as erectile dysfunction and vision loss

Stem Cell Therapy Type 2 Diabetes and Stem Cell Therapy for Diabetes Type 1
Stem cell therapy also can treat complications of diabetes including:

Diabetic foot: foot infections, ulcers, and deep layer tissue damage.

Diabetic retinopathy: it can cause blurred vision, decreased vision, and even blindness.

Diabetic cardiovascular and cerebrovascular diseases: it can cause a cerebral infarction, cerebral hemorrhage, vascular dementia, etc.

Diabetic neuropathy: it can cause numbness and tingle in hands and feet, orthostatic hypotension, vomiting, urinary, and fecal incontinence, etc.

Diabetic nephropathy(chronic renal failure): it can cause foamy urine, edema, and renal failure.

Capillary and macrovascular complications: diabetes can lead to narrowing of lower extremity arteries, coronary heart disease, stroke, etc.

Diabetes-Related Diseases That Stem Cell Therapy Can Treat
In 2019, the famous US news magazine “TIME” listed diabetes treatment with stem cell therapy as one of the top 10 innovative medical inventions that will change the future. In the year 2021, Mass General Brigham selected the ground-breaking “stem cell therapies for Diabetes” as one of the Top 12 “Disruptive gene and cell therapy technologies”.

Learn More About Diabetes
Diabetes is a metabolic disorder disease characterized by hyperglycemia(high blood sugar), it is also the third-largest non-infectious chronic disease following cancer and cardiovascular disease. There are approximately 537 million diabetes patients in the world by the year 2021.
Clinically, there are three main types of diabetes: type 1, type 2, and gestational diabetes (diabetes while pregnant). The major incidence populations of type 1 diabetes are adolescents and children, it is recognized by the destruction of pancreatic β-cells which leads to insufficient insulin secretion and hyperglycemia. Type 2 diabetes is caused by genetic, and environmental factors and their interactions. Usually, it is characterized by malfunction of pancreatic β-cell and insulin resistance in cells. Gestational diabetes develops in pregnant women who have never had diabetes before. If you have gestational diabetes, your baby could be at higher risk for health problems. Your baby is more likely to have obesity as a child or teen, and more likely to develop type 2 diabetes later in life too.

Risk Factors For Type 2 Diabetes

Type 2 diabetes is believed to have a strong genetic link, meaning that it tends to run in families. If you have a parent, brother, or sister who has it, your chances rise.

You should ask your doctor about a diabetes test when you have any of the following risk factors:

High blood pressure.

High blood triglyceride (fat) levels. It's too high if it's over 150 milligrams per deciliter (mg/dL).

Low "good" cholesterol level. It's too low if it's less than 40 mg/dL.

Gestational diabetes or giving birth to a baby weighing more than 9 pounds.

Prediabetes. That means your blood sugar level is above normal, but you don't have the disease yet.

Heart disease.

High-fat and carbohydrate diet. This can sometimes be the result of food insecurity when you don’t have access to enough healthy food.

High alcohol intake.

Sedentary lifestyle.

Obesity or being overweight.

Polycystic ovary syndrome (PCOS).

Being of ethnicity that’s at higher risk: African Americans, Native Americans, Hispanic Americans, and Asian Americans are more likely to get type 2 diabetes than non-Hispanic whites.

You're over 45 years of age. Older age is a significant risk factor for type 2 diabetes. The risk of type 2 diabetes begins to rise significantly around age 45 and rises considerably after age 65.

You’ve had an organ transplant. After an organ transplant, you need to take drugs for the rest of your life so your body doesn’t reject the donor. organ. These drugs help organ transplants succeed, but many of them, such as tacrolimus (Astagraf, Prograf) or steroids, can cause diabetes or make it worse.

Stem Cell Therapy For Diabetes At SQ1
Stem cells used in the treatment of diabetes
SQ1 provides access to treatment that utilizes mesenchymal stem cells (MSCs) isolated from the cord blood, placenta, and/or peripheral blood of patients and embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), into pancreatic endocrine lineages.

A combination MSCs and hESCs delivered via the intravenous route for 30 minutes at a delivery rate of 40 mL/hour to a final dose of 1 × 106 cells/kg of the patient's body weight.

The combination of cells and other treatment details are individual to the patient and is determined by genetically-programmed factors, individual to every human.

The therapeutic scope and efficacy of stem cell therapy for diabetes
A double infusion of hESCs+MSCs through either the intravenous route or the dorsal pancreatic artery route is performed for patients with type 2 Diabetes. The therapy exhibited term efficacy (7-9 months) in patients with type 2 diabetes for less than 10 years (the longest period of remission registered to date is 10 years and the shortest – 2 years) and a BMI <23 kg/m2 and improvement in hyperglycemia, reported blood glucose levels within the normal range.

Our results revealed reductions in the HbA1c and FBG levels during the first 3 months after administration in patients with type 2 Diabetes, deemed clinically significant because the reduction was maintained in a normal range at 12 months after administration.

Factors determining the efficacy of the treatment and remission term are individual and genetically driven.

Immunomodulation effect: stem cells can inhibit the T cell-mediated immune response against newly generated β cells and promote the repair and regeneration of pancreatic islets.

If you want to know more about stem cell medicine, please visit our website.